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CASR — EPHB2

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Vargas-Poussou et al., J Am Soc Nephrol 2002 (Bartter Syndrome...) : The kinetics of activation of the L125P mutant receptor expressed in HEK-293 cells, assessed by measuring CaSR stimulated changes in intracellular Ca ( 2+ ) and ERK activity, showed a dramatic reduction in the EC ( 50 ) for extracellular Ca ( 2+ ) compared with the wild-type and a loss-of-function mutant CaSR ( I40F )
Justinich et al., Am J Physiol Gastrointest Liver Physiol 2008 (Calcium Signaling) : CaSR stimulation by extracellular calcium or agonists, such as spermine or Mg ( 2+ ), caused ERK1 and 2 activation, intracellular calcium concentration ( [ Ca ( 2+ ) ] ( i ) ) mobilization ( as assessed by microspecfluorometry using Fluo-4 ), and secretion of the multifunctional cytokine IL-8 ( CX-CL8 )
Pallais et al., J Clin Endocrinol Metab 2011 (Autoimmune Diseases...) : The anti-CaSR antibody mediated inhibition of CaSR stimulated ERK1/2 activity, but not of inositol-1-phosphate accumulation, suggests that ERK1/2 may mediate, at least in part, the regulation of PTH secretion and urinary calcium excretion by the CaSR
Saidak et al., Pharmacol Ther 2012 (Osteoporosis) : Notably, activation of the calcium sensing receptor by strontium in osteoclasts or osteoblasts leads to activation of phospholipase Cß, inositol 1,4,5-triphosphate, release of intracellular Ca²?, and activation of MAPK ERK1/2 and Wnt/NFATc signaling
Ngo et al., Pediatr Res 2013 (Fibrosis) : Contraction of PA-stimulated and PA-unstimulated HEK-WT lattices did not differ.Conclusion : Exposure of intestinal epithelia to the EDGP analog PA stimulates CaSR dependent ERK phosphorylation and epithelial mediated collagen lattice contraction