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CXCL12 — IL18
Text-mined interactions from Literome
Damås et al., Circulation 2002
(Angina, Unstable) :
In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1,
interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Kanda et al., Eur J Immunol 2007
:
IL-18 enhances IFN-gamma induced production of CXCL9,
CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro
effects of
IL-18 on IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in human keratinocytes ...
IL-18 enhanced the IFN-gamma induced secretion and mRNA expression of CXCL9,
CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
IL-18 significantly
enhanced the production of
SDF-1alpha/CXCL12 , MCP-1/CCL2, and VEGF in RA ST fibroblasts, in a time- and concentration dependent manner ...
IL-18 induced
SDF-1alpha/CXCL12 up-regulation was dependent on JNK, p38 MAPK, phosphatidylinositol 3-kinase (PI3K), and NFkappaB ... While
IL-18 induced production of
SDF-1alpha/CXCL12 was also dependent on protein kinase Cdelta (PKCdelta), production of MCP-1/CCL2 was dependent on PKCalpha, not PKCdelta