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BCL2 — ITGAV

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BCL2 → Complex of ITGAV-ITGB3 (increases, BCL2 Activity) Soldi et al., EMBO J 1999
  Evidence: Integrin avb3 is expressed in high quantities on angiogenic endothelial cells (Brooks et al., 1994a), where it suppresses the activity of p53 and the p53-inducible cell-cycle inhibitor p21WAF1/CIP1 and increases the Bcl-2:Bax ratio, with a consequent antiapoptotic effect (Stromblad et al., 1996).