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BCL2 — PCBD1
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Yeo et al., Dev Biol 2003
:
We demonstrate that
PCD can be reproducibly
inhibited in vivo during primary neurogenesis by the overexpression of human
Bcl-2
Fombonne et al., Mol Biol Cell 2004
:
Moreover, overexpression of cell death inhibitor
Bcl-2 prevented not only the EGF induced
PCD but also its prodifferentiation effects, thus pointing to a mechanistic relationship existing between these two phenomena
Estoppey et al., Cell Death Differ 1997
:
Bcl-2 overexpression can
prevent programmed cell death (PCD) in different cell types ...
Bcl-2 can
inhibit PCD mediated by these proteases, although as yet it is not clear at what specific step in the cell death pathway the protein acts ... These results demonstrate that
Bcl-2 controls
PCD , by acting upstream of CPP32/Yama/Apopain
Gilbert et al., Cell Death Differ 1996
:
These results suggest that
Bcl-2 overexpression
inhibits PCD induced by the bioreductive cytotoxin SR4233 under aerobic conditions as well as PCD induced by hypoxia, and that there are other pathways leading to PCD that are unaffected by Bcl-2 overexpression
Muilenburg et al., J Surg Res 2010
(Pancreatic Neoplasms) :
Disruption of
Bcl-2 activity using the small molecule inhibitor A-779024
induces apoptotic but not autophagic
PCD
Merto et al., Cell Growth Differ 1997
:
Ectopic
Bcl-2 expression in MCF-10-A and HC11 mammary cells
results in a complete suppression of
PCD