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TNF — VIP

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP/PACAP inhibit the production of IL-12, IL-6, tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Holden et al., Med Hypotheses 1999 : beta-endorphin effects glucose metabolism in the limbic system, CCK increases the release of beta-endorphin from the anterior pituitary, NPY is a powerful anxiolytic that regulates beta-endorphin and insulin, while VIP indirectly regulates the expression of TNF-alpha through the inhibition of interleukin-4 (IL-4)
Delgado et al., J Neuroimmunol 1999 : We reported previously that VIP and PACAP inhibit IL-6, IL-12, TNF alpha and NO production, and enhance IL-10 production, from lipopolysaccharide (LPS) stimulated macrophages ... The VIP/PACAP inhibition of TNF alpha and NO occurs through both CD14 dependent and -independent mechanisms, whereas the inhibition of IL-6 production appears to be strictly CD14 dependent
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha , interleukin (IL)-6, nitric oxide, and IL-12
Kim et al., J Neurosci 2000 (Spinal Cord Injuries) : TNF-alpha protein levels were reduced 90 % by VIP or PACAP at 10 ( -7 ) m ... We conclude that VIP and PACAP inhibit the production of TNF-alpha from activated microglia by a cAMP dependent pathway
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha , IL-6, IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells ... VIP/PACAP inhibit TNF alpha through reduction in NFkB binding and changes in the composition of CRE binding complexes ; they inhibit IL-12 through reduction in NFkB binding and changes in the composition of the ets-2 complexes
Rameshwar et al., Exp Hematol 2002 : VIP induced the production of TGF-beta and TNF-alpha in BM mononuclear cells and stroma
Delgado et al., J Leukoc Biol 2003 : VIP and PACAP inhibit TNF-alpha , IL-1beta, IL-6, and NO production by lipopolysaccharide (LPS) activated microglia
Delgado et al., Biochem Biophys Res Commun 2003 : VIP was shown to inhibit IL-6, TNFalpha , IL-12, chemokine, and nitric oxide production in endotoxin activated macrophages
Hernanz et al., Regul Pept 2003 (Arthritis, Rheumatoid...) : In the present study, we have investigated the in vitro effect of calcitonin related peptide ( CGRP ), neuropeptide Y (NPY), substance P ( SP ) and vasoactive intestinal peptide (VIP) at concentrations of 10 ( -8 ), 10 ( -9 ) and 10 ( -10 ) M on the production of different proinflammatory cytokines or chemokines such as IL-1beta, IL-6 and TNFalpha by peripheral whole blood cells from patients with rheumatoid arthritis, as well as from osteoarthritis patients studied as a control group without immunoinflammatory background
Juarranz et al., Rheumatology (Oxford) 2004 (Arthritis, Rheumatoid...) : The effects of VIP on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ), CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Foey et al., Arthritis Res Ther 2003 (Arthritis, Rheumatoid) : VIP partially suppressed monocyte- and macrophage derived tumour necrosis factor alpha (TNF-alpha) with no effect on IL-10, whereas VIP fails to regulate IL-10 and TNF-alpha production by T lymphocytes
Zhang et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2005 : The VIP in culture supernatant potently inhibited TNF-alpha production by LPS induced Macrophages in vitro
Foster et al., J Dent Res 2005 : VIP ( 10 ( -8 ) M ) significantly ( P < 0.05 ) inhibits TNF-alpha production by human monocytic THP1 cells stimulated with Pg LPS
Dallos et al., Neuropeptides 2006 (Inflammation) : The aims of this study were a systematic investigation of the effects of the neuropeptides substance P ( SP ), calcitonin gene related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and galanin (GAL) on the inflammatory cytokine production ( IL-1alpha, IL-8 and TNF-alpha ) of the keratinocytes, and a study of their role in the production and secretion of nerve growth factor (NGF) and its precursor molecule ( proNGF )
Kelleher et al., J Immunol 1991 : Our results demonstrated that vasoactive intestinal peptide , the beta-adrenergic agonist, isoproterenol, PGE2, IL-1 alpha, IL-1 beta, and TNF-alpha significantly increased media SC levels in control or androgen containing cell cultures
Larocca et al., Int Immunopharmacol 2007 : VIP inhibited LPS induced TNF-alpha , IL-12 and nitrites accumulation in NOD macrophages while it increased IL-10 production
Luo et al., Eur J Pharmacol 2009 (Disease Models, Animal...) : Meanwhile, VIP significantly inhibited the release of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in concanavalin A-injected mice, but markedly elevated the production of anti-inflammatory cytokine interleukine-10 (IL-10)
Natsume et al., Int J Mol Med 2010 : Forskolin, a direct activator of adenylyl cyclase, or 8-bromoadenosine-3',5'-cyclic monophosphate ( 8bromo-cAMP ), a plasma membrane-permeable cAMP analogue, markedly enhanced the TNF-alpha induced IL-6 synthesis as well as VIP
Nair et al., Cell Immunol 1995 : VIP at all concentrations tested did not induce TNF production and was similar to untreated control cultures
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ), somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people ... The TNF alpha production was stimulated by NPY and somatostatin in young subjects, and by NPY, somatostatin and VIP in old ones, whereas GRP produced a decrease of TNF alpha in young persons ... On the contrary, GRP and VIP inhibited highly the LPS induced TNF alpha production in young controls
Xin et al., J Neuroimmunol 1998 : In this study, we investigated the effect of VIP on IL-12, TNF alpha and nitric oxide ( NO ) production in macrophages following activation with lipopolysaccharide (LPS) or superantigens ... In vitro studies show that at physiologic concentrations, VIP inhibited IL-12 and NO but not TNF alpha production in macrophages which were stimulated with LPS or superantigens
Delgado et al., J Immunol 1999 : Previous reports showed that VIP/PACAP inhibit IL-6 and TNF-alpha production in LPS stimulated macrophages
Delgado et al., J Immunol 1999 (Inflammation) : In this study we have investigated the effects of VIP and the structurally related neuropeptide pituitary adenylate cyclase activating polypeptide ( PACAP38 ) on the production of TNF-alpha by endotoxin activated murine peritoneal macrophages ... VIP and PACAP regulate the production of TNF-alpha at a transcriptional level