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CDK4 — RELA
Text-mined interactions from Literome
Chandramohan et al., J Immunol 2004
:
B cell receptor (BCR) engagement of murine WEHI 231 immature B lymphoma cells leads sequentially to a drop in
NF-kappa B and c-Myc, and
induction of the p27 ( Kip1 )
cyclin dependent kinase inhibitor, which promotes growth arrest and apoptosis
Thoms et al., Cancer Res 2007
(Colorectal Neoplasms...) :
Furthermore, chemical inhibition of the cyclin
D1/cyclin dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degradation,
caused nucleolar translocation of
RelA , repression of kappaB-driven transcription, and apoptosis, thereby reproducing the effects of aspirin ... In addition, we found that aspirin and the
CDK4 inhibitor
induced nucleolar translocation of
RelA and apoptosis through a common mechanism involving the NH ( 2 ) -terminal nucleolar localization signal
Thoms et al., Cell cycle (Georgetown, Tex.) 2007
(Adenocarcinoma...) :
Specific inhibition of
CDK4 activity
induced translocation of
RelA , the principal component of NFkappaB, from the cytoplasm to the nucleoplasm and then to the nucleolus
Lee et al., American journal of physiology. Renal physiology 2008
:
Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or
NF-kappaB blocked the BSA induced increases in cyclin D1,
cyclin dependent kinase (CDK)4, cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression ... Consequently, the inhibition of Ca ( 2+ ), PKC, EGFR, p44/42 MAPKs, or
NF-kappaB blocked the BSA induced increases in cyclin D1, cyclin dependent kinase
(CDK)4 , cyclin E, or CDK2 and restored the BSA induced inhibition of p21 ( WAF/Cip1 ) and p27 ( Kip1 ) expression