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CSNK1A1L — RELA

Text-mined interactions from Literome

Wang et al., Biochemistry 2008 : In a kinase gene screen using a NF-kappaB reporter, we observed that overexpression of casein kinase 1alpha (CK1alpha) enhanced TNFalpha induced NF-kappaB activation, and a CK1alpha kinase dead mutant, CK1alpha ( K46A ), reduced NF-kappaB activation induced by TNFalpha ... Finally, we showed that CK1alpha enhanced RIP1 mediated NF-kappaB activation
Bidère et al., Nature 2009 (Lymphoma, Large B-Cell, Diffuse) : ABC DLBCL cells required CK1alpha for constitutive NF-kappaB activity, indicating that CK1alpha functions as a conditionally essential malignancy gene-a member of a new class of potential cancer therapeutic targets