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PAWR — RELA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Ceramide signaling pathway: PKC zeta/PAR4 complex (PRKCZ-PAWR) → NF kappa B1/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA) (modification, inhibits)
  
• NCI Pathway Database Ceramide signaling pathway: PKC zeta/PAR4 complex (PRKCZ-PAWR) → NF kappa B1/RelA/I kappa B alpha complex (NFKB1-RELA-NFKBIA) (modification, inhibits)
  

Text-mined interactions from Literome

Camandola et al., J Neurosci Res 2000 : We now report that overexpression of full-length Par-4 in cultured PC12 cells results in a suppression of basal NF-kappaB DNA binding activity and NF-kappaB activation following trophic factor withdrawal ( TFW )
Chendil et al., Cancer Biol Ther 2002 (Prostatic Neoplasms) : Par-4 , a pro-apoptotic gene, inhibits radiation induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3
El-Guendy et al., Mol Cell Biol 2003 : In the present study, structure-function analysis indicated that inhibition of NF-kappaB activity and apoptosis is dependent on Par-4 translocation to the nucleus via a bipartite nuclear localization sequence, NLS2