Luchtefeld et al., Biochem Biophys Res Commun 2003
:
Since NAD ( P ) H-oxidase activation by cytokines involves 5-lipoxygenase ( LOX ) -derived leukotriene B ( 4 ) ( LTB ( 4 ) ) formation, we postulated that LTB ( 4 ) is involved in the ANG II-dependent NAD ( P ) H-oxidase activation ... LTB ( 4 ) activates the vascular type NAD ( P ) H-oxidase , leading to an increase in IL-6 transcripts
Lindsay et al., J Immunol 1998
:
Experiments were designed to investigate whether leukotriene ( LTB4 ) receptors can couple directly to phospholipase A2 (PLA2) in guinea pig eosinophils and the role of endogenous arachidonic acid ( AA ) in LTB4 induced activation of the NADPH oxidase