Yi et al., Cell Physiol Biochem 2007
:
Mechanism of homocysteine induced Rac1/NADPH oxidase activation in mesangial cells : role of guanine nucleotide exchange factor Vav2 ... These results suggest that Vav2 importantly contributes to Hcys induced increase in Rac1 activity and consequent activation of NADPH oxidase in RMCs via ceramide associated tyrosine phosphorylation
Yi et al., Hypertension 2009
(Disease Models, Animal...) :
We concluded that Vav2 mediated activation of NADPH oxidase is an important initiating mechanism resulting in hyperhomocysteinemic glomerular injury through enhanced local oxidative stress