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IFNG — SMAD7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kavsak et al., Mol Cell 2000
:
IFN gamma , which stimulates expression of Smad7,
induces Smad7-Smurf2 complex formation and increases TGF beta receptor turnover, which is stabilized by blocking Smad7 or Smurf2 expression
Sumiyoshi et al., J Dermatol Sci 2003
:
TGF-beta/Smad signaling
inhibits IFN-gamma and TNF-alpha induced TARC ( CCL17 ) production in HaCaT cells
Kuga et al., Oncogene 2003
(Neoplasm Invasiveness...) :
TGF-beta accelerated the phosphorylation of Smad2/3 and nuclear translocation of the Smad2/3-Smad4 complex in GCTM-1, but these TGF-beta induced effects were significantly inhibited by
IFN-gamma induced
Smad7 expression
Wen et al., Am J Respir Cell Mol Biol 2004
:
These results suggest that
IFN-gamma down
regulates TGF-beta2 production by HBECs by regulating
Smad 7
Monteleone et al., Gastroenterology 2004
(Helicobacter Infections) :
Induction of
Smad7 by
interferon (IFN)-gamma was examined in normal gastric mucosal biopsy specimens, whereas the effect of Smad7 inhibition on the ongoing Th1 response was analyzed in Hp-colonized biopsy specimens ...
Smad7 was
inducible in normal gastric biopsy specimens by
interferon-gamma through a STAT1 dependent mechanism, and neutralization of interferon-gamma in biopsy specimens from Hp-infected patients reduced Smad7 expression ... These data suggest that, in Hp-infected gastric mucosa,
interferon-gamma induces the expression of
Smad7 , which then prevents endogenous TGF-beta 1 from down regulating the ongoing tissue damaging Th1 response
Dooley et al., J Biol Chem 2006
(Carbon Tetrachloride Poisoning...) :
Here, we report that YB-1 activation via the Jak1 signaling pathway is required and sufficient to confer
interferon-gamma dependent activation of the
smad7 gene
Thomas et al., Cancer Cell 2005
:
Repression of granzyme B and
interferon-gamma involves binding of TGF-beta activated
Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway
Weng et al., Hepatology 2007
(Disease Models, Animal...) :
Furthermore, an
interferon gamma treatment of patients with chronic hepatitis B virus infection
induced Smad7 expression in hepatocytes, leading to decreased CTGF expression and fibrogenesis
Tanaka et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental) :
TGF-beta mediated
Smad transcriptional activity was severely inhibited in SOCS1-deficient cells in the
presence of
IFN-gamma ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in
IFN-gamma mediated
Smad suppression