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CDH1 — ILK

Text-mined interactions from Literome

Tan et al., Oncogene 2001 (Adenomatous Polyposis Coli...) : Strikingly, inhibition of ILK also resulted in the transcriptional stimulation of E-cadherin expression and correlated with the inhibition of gene transcription of snail, a repressor of E-cadherin gene expression
Vespa et al., J Biol Chem 2003 : A central component of integrin adhesion complexes is integrin linked kinase (ILK) , which can induce loss of E-cadherin expression and epithelial-mesenchymal transformation when ectopically expressed in intestinal and mammary epithelia ... Further, and in contrast to what is observed in other epithelial cells, ILK overexpression in differentiated keratinocytes does not promote E-cadherin down-regulation and epithelial-mesenchymal transition
Li et al., J Clin Invest 2003 (Fibrosis...) : Forced expression of ILK in human kidney proximal tubular epithelial cells suppressed E-cadherin expression and induced fibronectin expression and its extracellular assembly
Plante et al., Toxicological sciences : an official journal of the Society of Toxicology 2005 (Carcinoma, Hepatocellular...) : Mimicking the activation of ILK with specific GSK3beta inhibitors resulted in downregulation of E-cadherin levels but had no effect on Cx32 expression in the MH ( 1 ) C ( 1 ) cells
Chen et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 : The expression of a-smooth muscle actin ( a-SMA ) and E-cadherin were detected using a two-color immunohistochemistry staining technique, while the expression of integrin linked kinase (ILK) was detected using a one-color immunohistochemistry staining technique
McPhee et al., Dev Dyn 2008 : We show here that Integrin Linked Kinase (ILK) regulates E-cadherin expression through Poly(ADP-ribose) polymerase-1 ( PARP-1 ) ... ILK overexpression in Scp2 cells resulted in stimulation of Snail expression and loss of E-cadherin expression ... We suggest a model in which ILK represses E-cadherin expression by regulating PARP-1, leading to the binding of PARP-1 to SIRE and modulation of Snail expression
Goulioumis et al., Virchows Arch 2008 (Carcinoma, Squamous Cell...) : Previous in vitro studies also implicate ILK in the activation of Akt and beta-catenin as well as in the regulation of E-cadherin expression
Chen et al., Zhong Xi Yi Jie He Xue Bao 2009 : The expressions of alpha-smooth muscle actin ( alpha-SMA ) and E-cadherin were detected by two-color immunohistochemical staining, while the expressions of TGF-beta1 and ILK were detected by one-color immunohistochemical staining
Li et al., J Am Soc Nephrol 2009 (Disease Models, Animal...) : Pharmacologic inhibition of ILK with small-molecule inhibitor QLT-0267 abolished TGF-beta1 induced phosphorylation of Akt and glycogen synthase kinase-3beta, suppressed cyclin D1 expression, and largely restored the expression of E-cadherin and zonula occludens 1
Gil et al., Adv Enzyme Regul 2011 (Melanoma) : Silencing of ILK expression by siRNA significantly inhibited the stabilization and subsequent nuclear translocation of ß-catenin and the expression of N-cadherin , a crucial molecule in the EMT, which facilitates association with fibroblast and endothelial cells during invasion of various cancers
Chen et al., Acta Histochem 2013 (Carcinoma, Non-Small-Cell Lung...) : In addition, the down-regulation of E-cadherin induced by ILK was significantly reversed by nuclear factor-?B ( NF-?B ) inhibitor BAY 11-7028 and small interfering RNA ( siRNA ) targeting NF-?B p65, suggesting a role of the NF-?B signaling pathway in ILK induced EMT
Al-Ghamdi et al., Pancreas 2013 (Neoplasm Invasiveness...) : Evaluation of downstream targets demonstrated that alterations in CTEN levels induced changes in focal adhesion kinase and E-cadherin , whereas integrin linked kinase (ILK) remained unchanged ... Evaluation of downstream targets demonstrated that alterations in CTEN levels induced changes in focal adhesion kinase and E-cadherin , whereas integrin linked kinase (ILK) remained unchanged
Rodríguez et al., PLoS Genet 2013 (Breast Neoplasms...) : We also demonstrated that vimentin expression was sufficient to induce increased mesenchymal/pro-metastasic phenotypic changes in melanoma cells, including ILK/GSK3-ß dependent E-cadherin down-regulation, Snail1 activation and increased cell motility and migration
Wu et al., J Biol Chem 1998 (Cell Transformation, Neoplastic) : Integrin linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity