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CNTF — JAK1
Text-mined interactions from Literome
Peterson et al., J Neurosci 2000
:
CNTF induced
activation of
Jak-STAT signaling prompted us to investigate STAT3 phosphorylation after a variety of stress mediated, conditioning stimuli
Kaur et al., J Neurochem 2005
:
Inducers of oxidative stress block
ciliary neurotrophic factor activation of
Jak/STAT signaling in neurons ... Treatment with hydrogen peroxide ( H ( 2 ) O ( 2 ) ) as a generator of ROS inhibited
CNTF mediated
Jak/STAT signaling in all cultured nerve cells tested, including chick ciliary ganglion neurons, chick neural retina, HMN-1 motor neuron hybrid cells, and SH-SY5Y and BE ( 2 ) -C human neuroblastoma cells
Fischer et al., Mol Cell Neurosci 2008
(Disease Models, Animal...) :
Furthermore beta-crystallin induced
CNTF expression in retinal astrocytes and
activation of CNTF 's major downstream signaling pathway (
JAK/STAT3 ) when intravitreally injected or added to the culture medium ex vivo
Rhee et al., Adv Exp Med Biol 2010
:
CNTF/LIF activates
Jak-STAT , ERK, and Notch pathways during retinal development
Bonni et al., Science 1997
:
Although
CNTF stimulated both the Janus kinase-signal transducer and activator of transcription (
JAK-STAT ) and Ras-mitogen activated protein kinase signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway selectively enhanced differentiation of these precursors along a glial lineage