◀ Back to ERBB2
ERBB2 — JUN
Text-mined interactions from Literome
Naderi et al., Int J Cancer 2012
(Breast Neoplasms) :
In this feedback loop,
ErbB2 overexpression
results in an induction of
c-Jun and BEX2 expression ... In turn, the overexpression of BEX2 led to an increase in both
c-Jun mediated
induction of
ErbB2 and c-Jun binding to the ErbB2 promoter in MCF-7 cells
Monden et al., Oncol Rep 1996
:
However, azatyrosine inhibited increases in phosphorylation of c-Raf-1 and
c-Jun induced by oncogenic
c-ErbB-2
Galang et al., J Biol Chem 1996
(Cell Transformation, Neoplastic) :
Oncogenic
Neu/ErbB-2 increases ets,
AP-1 , and NF-kappaB dependent gene expression, and inhibiting ets activation blocks Neu mediated cellular transformation