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APOB — VEGFA

Text-mined interactions from Literome

Inoue et al., Arterioscler Thromb Vasc Biol 2001 (Arteriosclerosis) : Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator activated receptor-gamma ... Therefore, we investigated the involvement of PPARgamma in the regulation of VEGF by Ox-LDL ... TRO and Ox-LDL augmented VEGF expression in U937T ... In conclusion, Ox-LDL upregulates VEGF expression in macrophages and endothelial cells, at least in part, through the activation of PPARgamma
Salomonsson et al., Eur J Clin Invest 2002 (MAP Kinase Signaling System) : Post-transcriptional regulation of VEGF expression by oxidised LDL in human macrophages
Rodríguez et al., Cardiovasc Res 2005 (Hypercholesterolemia) : Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL ... HC-LDL , with high cholesterol ( P < 0.05 ) and reduced tocopherol/cholesterol ratio ( P < 0.05 ), increased significantly VEGF and VEGFR-2 ( p < 0.001 ) in EC, associated with higher O ( 2 ) ( - ) and HIF-1 alpha expression, in comparison with C-LDL and HCV-LDL ... Our data suggest HC-LDL induce endothelial VEGF and VEGFR-2 overexpression at least by increasing oxidative stress, and HIF-1 alpha is one of the signaling mechanisms involved
Trapé et al., Scand J Clin Lab Invest 2006 (Atherosclerosis...) : VEGF expression is regulated by hypoxia, cytokines, oncogenes, and oxidized low-density lipoprotein (LDL)
Kanata et al., Biochem Biophys Res Commun 2006 : Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma ... Ox-LDL markedly increased VEGF mRNA expression and protein release in time- and dose dependent manners, which was significantly suppressed by anti-LOX-1 antibody pretreatment ... The specific PPAR-gamma inhibitor GW9662 suppressed ox-LDL induced VEGF expression
Usui et al., EMBO Rep 2007 : Here we report that native LDL ( nLDL ) activates vascular endothelial growth factor ( VEGF ) receptor 1 ( VEGFR1 ) but not VEGFR2 through LDLR and is as potent as VEGF in macrophage migration
Moreira et al., Invest Ophthalmol Vis Sci 2009 (Choroidal Neovascularization) : In ARPE19 cells and HMVECs, oxidized LDL and 7kCh induced VEGF 8- to 10-fold above controls
Liu et al., Phytomedicine 2009 (Atherosclerosis) : The aim of this study was to investigate whether Ox-LDL regulates VEGF expression in human THP-1 monocytes, as well as the effect of EGb 761 on VEGF expression and the formation of foam cells ... Ox-LDL markedly increased VEGF expression in THP-1 cells in a time- and concentration dependent manner, which was significantly suppressed by EGb 761
Kuzuya et al., Nihon Ronen Igakkai Zasshi 1998 (Arteriosclerosis) : In the present study, we examined the role of inflammatory cytokines and oxidative modified low density lipoprotein ( OX-LDL ) in the expression of macrophage VEGF
Ramos et al., Arterioscler Thromb Vasc Biol 1998 (Arteriosclerosis) : Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions ... The current study demonstrated that Ox-LDL upregulated vascular endothelial growth factor ( VEGF ) mRNA expression in RAW 264 cells, a monocytic cell line, in a time- and concentration dependent manner and that Ox-LDL stimulated VEGF protein secretion from the cells