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WNT1 — WNT2
Text-mined interactions from Literome
Cha et al., Hepatology 2004
(Carcinoma, Hepatocellular...) :
We found that
Wnt/beta-catenin signaling could be
activated by ectopic expression of
Wnt-1 in some hepatoma cells, such as Hep3B and PLC/PRF/5 cells, but not in others, such as Huh7 and Chang cells ... In conclusion, the data suggest that
Wnt-1 is necessary but insufficient to activate Wnt/beta-catenin signaling in hepatoma cells and the enhanced stabilization of beta-catenin by HBx, in addition to Wnt-1, is
essential for the activation of
Wnt/beta-catenin signaling in hepatoma cells
Le Floch et al., FASEB J 2005
(Colonic Neoplasms...) :
Upstream
activation of
Wnt signaling by the Wnt-2 and Wnt-3a ligands, stable overexpression of
Wnt-2 , as well as GSK-3beta inhibition by lithium, SB216763, and GSK-3beta dominant negative forms ( K85R and R96E ) conferred the invasive phenotype through several proinvasive pathways
Shi et al., Int J Cancer 2007
(Colorectal Neoplasms) :
In this study, we investigated
roles of
Wnt-2 and Gal-3 in the regulation of canonical
Wnt/beta-catenin signaling
Bayle et al., J Invest Dermatol 2008
(Scleroderma, Systemic) :
Increased expression of
Wnt2 and SFRP4 in Tsk mouse skin :
role of
Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
Falk et al., Cell stem cell 2008
:
In the midbrain, but not in the forebrain, Tgfbr2 ablation results in ectopic expression of
Wnt1/beta-catenin and FGF8,
activation of
Wnt target genes, and increased proliferation and horizontal expansion of neuroepithelial cells due to shortened cell-cycle length and decreased cell-cycle exit
Inadera et al., Biochem Biophys Res Commun 2009
:
Wnt signaling negatively regulates adipocyte differentiation, and ectopic expression of
Wnt-1 in 3T3-L1 cells
induces several downstream molecules of Wnt signaling, including Wnt-1 inducible signaling pathway protein ( WISP)-2
Teissedre et al., PloS one 2009
(Mammary Neoplasms, Animal) :
Using axin2/conductin reporter genes we show that
MMTV-Wnt1 and MMTV-DeltaN89beta-catenin
activate canonical
Wnt signaling within distinct cell-types
Lin et al., FEBS Lett 2011
(Prostatic Neoplasms) :
We also found that Mesd suppressed
Wnt/ß-catenin signaling
induced by
Wnt1 in prostate cancer PC-3 cells, and inhibited tumor growth in PC-3 xenograft model
Duan et al., EMBO J 2012
(Fibrosis...) :
The injured regions in the heart are
Wnt responsive as well and
Wnt1 induces cardiac fibroblasts to proliferate and express pro-fibrotic genes
Reis et al., J Exp Med 2012
(Brain Neoplasms...) :
In this study, we show that doxycycline dependent
Wnt1 expression in subcutaneous and intracranial mouse glioma models
induced endothelial
Wnt/ß-catenin signaling and led to diminished tumor growth, reduced vascular density, and normalized vessels with increased mural cell attachment
Smolich et al., Dev Biol 1994
(Carcinoma, Embryonal) :
In the
presence of ectopic
Wnt-1 , expression of other endogenous
Wnt genes, which serve as early differentiation markers in this system, were induced without RA, which is normally required for appearance of these gene products