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CRK — RELA

Text-mined interactions from Literome

Rovin et al., Cytokine 1999 : Because NF-kappaB is necessary for MCP-1 gene expression, the effect of p38 kinase inhibition on IL-1beta induction of NF-kappaB was measured
Ingram et al., American journal of physiology. Renal physiology 2000 : Thus strain induces p38 activity and translocation to the nucleus and p38 dependent increases in nuclear protein binding to NF-kappaB
Bauer et al., Shock 2000 : Adherence alone did not activate p38MAPK or NF-kappaB, but primed Mphi for an augmented response to LPS in activation of p38 , NF-kappaB and in production of TNF-alpha
Tsukagoshi et al., Regul Pept 2001 : ANP inhibited the IFN-gamma induced p38 MAP kinase activation, and ANP and SB203580 inhibited NF-kappaB activation
Xu et al., Biochem J 2001 : Nuclear factor-kappaB (NF-kappaB) , a previously identified positive regulator of MMP-1 expression induced by fl-coll [ Xu, Zutter, Santoro and Clark ( 1998 ) J. Cell Biol. 140, 709-719 ] was mediated by fl-coll activated p38alpha
Ivanov et al., Oncogene 2001 (Melanoma) : Conversely, activation of IKK attenuates the sensitization of melanoma by TRAF2DeltaN, indicating that p38 mediated suppression of NF-kappaB activity is among TRAF2DeltaN effects
Guo et al., J Cell Biochem 2001 : While it is unclear whether p38beta regulates NF-kappaB transcription activity at other steps, it is apparent that p38beta does not affect TNF-alpha induced NF-kappaB activation at the stage of nuclear translocation
Jijon et al., Am J Physiol Cell Physiol 2002 : Furthermore, AP-1 and NF-kappaB DNA binding was not affected by ERK and p38 inhibition
Waldhoer et al., J Virol 2002 : The use of specific inhibitors indicated that the p38 mitogen activated protein ( MAP ) kinase but not the extracellular signal regulated kinase 1/2-MAP kinase pathway is involved in M33- and US28 mediated CREB activation but not NF-kappaB activation
Park et al., Science 2002 (MAP Kinase Signaling System...) : Because macrophages that are deficient in transcription factor nuclear factor kappaB (NF-kappaB) are also sensitive to activation induced death and p38 is required for expression of certain NF-kappaB target genes, p38 is probably essential for synergistic induction of those NF-kappaB target genes that prevent apoptosis of activated macrophages
Shimada et al., Carcinogenesis 2003 (Prostatic Neoplasms) : The results suggest that not only p53 induction through p38/JNK dependent NFkappaB/AP-1 activation but also JNK dependent Bcl-2 phosphorylation are required for 2-ME induced apoptosis ; moreover, inhibition of these pathways may be involved in androgen mediated resistance to apoptosis
Le Page et al., Biol Chem 2003 (Inflammation) : In RAW264.7 macrophages the inducers of NF-kappaB activate the production of reactive oxygen species and three mitogen activated protein kinases ( MAPK ), the extracellular signal regulated kinase ( ERK ), the c-jun N-terminal kinase/stress activated protein kinase ( JNK ), and p38
Baeza-Raja et al., Mol Biol Cell 2004 : Activation of p38 in C2C12 cells induced the activity of NF-kappaB, in a dual way : first, by reducing IkappaBalpha levels and inducing NF-kappaB-DNA binding activity and, second, by potentiating the transactivating activity of p65-NF-kappaB
Nojek et al., Medicina (B Aires) 2004 : We determined that : 1 ) the p38 specific inhibitor reduces 50 % NF-kappaB transcriptional activity, even in cells that overexpress distinct TIF2 deletions ; 2 ) there is a physical interaction between TIF2 and p38 and RelA determined through in vitro translated protein binding assays ; 3 ) TIF2 is a p38 substrate ; 4 ) there is a physical interaction between TIF2 and IKK in TNF-alpha 20 ng/ml stimulated or not HEK 293 cell protein extract, and IkappaB only in basal conditions, determined by binding pull down assays
Ueno et al., Cardiovasc Toxicol 2006 (Atherosclerosis) : Our results indicate that nicotine enhances the expression of ICAM-1 and VCAM-1 on the endothelial cell surface via a second messenger pathway which involves PKC and p38 MAPK mediated activation of NF-kappaB and AP-1, resulting in increased expression of these cellular adhesion molecules
Kim et al., Eur J Pharmacol 2006 : Cordycepin inhibits lipopolysaccharide induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells
Li et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : JAK1/TYK2 leads to STAT3 activation, Akt dependent NF-kappaB activation , and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Kang et al., Biochem Pharmacol 2008 : SK-126 enhanced ERK1/2 and p38 activation following LPS stimulation, but it did not induce phosphorylation of SAPK/JNK and NF-kappaB
Zhao et al., J Cardiovasc Pharmacol 2008 : Our findings suggest that aspirin can decrease inflammatory responses induced by ox-LDL, and the mechanism might be associated with NF-kappaB activation pathway and inhibition of p38 MAPK phosphorylation
Noman et al., Innate Immun 2009 : Thalidomide prevented the activation of nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS induced phosphorylation of AKT, p38 and stress activated protein kinase ( SAPK ) /JNK
Ming et al., BMC cardiovascular disorders 2009 : Moreover, the inhibitory effect of L-norvaline was not reversed by the NOS inhibitor L-NAME and L-norvaline did not interfere with TNFalpha induced activation of NF-kappaB , JNK, p38mapk , while it inhibited p70s6k ( S6K1 ) activity
Kim et al., Rheumatology (Oxford) 2009 (Osteoarthritis) : MAP kinases [ p38 , extracellular signal regulated protein kinase ( ERK ) and C-Jun N terminal kinase (JNK) ] and NF-kappaB activation were evaluated by western blotting and by an electrophoretic mobility shift assay, respectively
Weng et al., J Biomed Sci 2009 (Liver Cirrhosis, Biliary...) : Arm also suppressed TNF-alpha induced collagen collagen deposition, NFkappaB activation and MAPK ( p38 , ERK1/2, and JNK ) phosphorylations
Qin et al., J Immunol 2009 (Arthritis, Experimental) : HMGB1 promotes the phosphorylation of MAPK p38 and the activation of NF-kappaB through RAGE, and then enhances the expression of proinflammatory cytokines
Khan et al., Mol Cell Biochem 2010 (Escherichia coli Infections...) : In this article, we have shown that EAEC induced activation of mitogen activated protein kinases ( MAPK ) ( ERK-1/2, JNK and p38MAPK ) in cultured human intestinal epithelial cells ( INT-407 ) leads to the induction of DNA binding activity of NF-kappaB and AP-1, resulting in IL-8 production
Chen et al., Exp Eye Res 2010 (Dry Eye Syndromes) : p38 inhibitor suppressed hyperosmoticity induced NF-kappaB activation, indicating that NF-kappaB activation was dependent on p38 activation
Cao et al., Int Immunopharmacol 2010 (Disease Models, Animal...) : We further observed that MA prevented the LPS induced nuclear factor-kappa B (NF-kappaB) translocation from the cytoplasm into the nucleus, and inhibited the LPS induced phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38
Damgaard et al., Discov Med 2011 (Inflammation) : Recent evidence suggests that cIAP1, cIAP2, and XIAP facilitate ubiquitin dependent signaling activated by these PRRs and mediate activation of nuclear factor-kappa B (NF-kappaB) transcription factors as well as the MAP kinases p38 and JNK
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Modur et al., J Biol Chem 1996 : Thus activation of the ERK cascade alone is an incomplete endothelial cell stimulus, and the TNF receptor generates at least two signals : Raf-1 activation, which could be ceramide dependent ; and ceramide independent efficient NF-kappaB translocation and activation of p38 and JNK-1 mitogen activated kinases