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BCRP8 — MYLIP

Text-mined interactions from Literome

Jiao et al., Breast Cancer Res Treat 2013 : Overexpression of miR-181a down-regulated BCRP expression, and sensitized MX-resistant MCF-7/MX cells to MX ... In addition, miR-181a inhibitors up-regulated BCRP expression, and rendered MX-sensitive MCF-7 cells resistant to MX ... These findings suggest that miR-181a regulates BCRP expression via binding to the 3'-UTR of BCRP mRNA
Ma et al., Cancer Lett 2013 (Breast Neoplasms...) : Moreover, ectopic miR-487a down-regulated BCRP expression at the mRNA and protein levels, increasing the intracellular accumulation and cytotoxicity of MX in resistant MCF-7/MX breast cancer cells ... Meanwhile, inhibition of miR-487a increased BCRP expression at the mRNA and protein levels and induced MX resistance in sensitive MCF-7 breast cancer cells ... Thus, our results suggested that miR-487a can directly regulate BCRP expression and reverse chemotherapeutic drug resistance in a subset of breast cancers