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CAV3 — IL6
Text-mined interactions from Literome
Podar et al., J Biol Chem 2003
(Multiple Myeloma) :
Interleukin-6 and insulin-like growth factor-I, growth and survival factors in multiple myeloma,
induce caveolin-1 phosphorylation, which is abrogated by pre-treatment with beta-cyclodextrin
Wang et al., Am J Respir Cell Mol Biol 2006
(Inflammation) :
Loss-of-function experiments using small interfering RNA showed that down regulating
caveolin-1 expression in murine alveolar and peritoneal macrophages
increased LPS induced proinflammatory cytokine TNF-alpha and
IL-6 production but decreased anti-inflammatory cytokine IL-10 production
Wu et al., J Neurosurg 2010
(Brain Injuries...) :
Simvastatin modified the
caveolin-1 expression in lipid rafts in astrocyte cell membrane, suppressed the phosphorylation of EGFR in lipid rafts of astrocytes after OGD, and
inhibited the OGD induced
interleukin-1 production
Lv et al., Inflamm Res 2010
(Inflammation) :
Over-expression of
caveolin-1 not only
increased the production of pro-inflammatory cytokine TNF-alpha and
IL-6 , but also enhanced the expression of the cPLA2, p38 MAPK, and NF-kappaB
Hung et al., J Hypertens 2010
(Atherosclerosis) :
Because eNOS and caveolin-1 are crucial for vascular tone control, we studied the
effects of
IL-6 on the expression and activation of eNOS and
caveolin-1 in human vascular endothelial cells ... Furthermore, treatment with PD98059 and short interference RNA of extracellular signal regulated kinase gene reversed the
effects of
IL-6 on eNOS and
caveolin-1
Wang et al., Am J Physiol Endocrinol Metab 2011
:
Here, we address whether
caveolin-1 is required for the first step of insulin 's transendothelial transport, its uptake by vascular endothelial cells ( ECs ), and whether
IL-6 and TNFa
affect insulin uptake or caveolin-1 expression ...
IL-6 or TNFa also significantly
reduced plasma membrane associated
caveolin-1