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GAB1 — PIK3R2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of GAB1-PIK3R2 (decreases)
  Evidence: In the parentalHCC827 cell line, two major phosphotyrosine proteins, ERBB3 (~240 KD) and growth-factor-receptor bound protein 2 (Grb2) associated binder 1 (Gab1) (~120 KD), a known PI3K adaptor protein (14), coprecipitated with p85 (Fig. 2C), and both interactions were disrupted by gefitinib alone.
• KEGG Neurotrophin signaling pathway: GAB1 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, binding/association)
  
• KEGG Bacterial invasion of epithelial cells: GAB1 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Renal cell carcinoma: GAB1 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG ErbB signaling pathway: GAB1 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• Reactome Reaction: PIK3R2 → GAB1 (indirect_complex)
• WikiPathways ESC Pluripotency Pathways: GAB1 → PIK3CD/PIK3R2 (activation)
• WikiPathways Signaling Pathways in Glioblastoma: GAB1 → Complex of PIK3R1-PIK3R2-PIK3CA-PIK3CB-PIK3CD (mim-stimulation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009