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IL6 — MAP3K7
Text-mined interactions from Literome
Kobayashi et al., J Biol Chem 2005
:
Ser412 -- > Ala
TAK1 also
inhibited the forskolin induced up-regulation of
interleukin 6 production in RAW264.7 cells treated with lipopolysaccharide
Kojima et al., Proc Natl Acad Sci U S A 2005
:
STAT3 regulates Nemo-like kinase by mediating its interaction with
IL-6 stimulated
TGFbeta activated kinase 1 for STAT3 Ser-727 phosphorylation ... Depletion of STAT3 diminished the IL-6 induced NLK activation by > 80 % without inhibiting
IL-6 induced
TAK1 activation or its nuclear entry
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3
inhibits interleukin-1 signaling by targeting the
TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006
:
YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and
interleukin-1-inducible activation of endogenous
TAK1 , TAB1 and TAB2
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced
activation of
TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009
(Colitis) :
Finally, we showed that
TAK1 is
essential for
interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2
Fukuno et al., Biochem Biophys Res Commun 2011
:
We also confirmed that
TAK1 mediates cyclic stretch induced
IL-6 protein synthesis in the cells using immunoblotting and ELISA
Hamidi et al., J Biol Chem 2012
(Inflammation) :
Expression of a K34R-mutant
TAK1 led to a reduced NF-?B activation,
IL-6 promoter activity, and proinflammatory cytokine secretion by TNF-a stimulated PC-3U cells
Arcipowski et al., PloS one 2012
:
We determined that
TAK1 was
required for JNK activation and
interleukin-6 (IL-6) production mediated by CD40 and LMP1, in both mouse and human B cells