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EGFR — IFI27

Text-mined interactions from Literome

Sheng et al., Mol Biol Cell 2005 : Futhermore, the V1 isoform was able to not only activate proto-oncogene EGFR expression and modulate its downstream signaling pathway, but also induce p27 degradation and enhance CDK2 kinase activity
Langner et al., BJU Int 2005 (Carcinoma, Renal Cell...) : During progression to category pT1b, expression of p27 significantly decreased ( 54 % ) and EGFR expression increased ( 38 % )
Santra et al., J Cereb Blood Flow Metab 2006 (Glioma) : Blocking of phosphoinositide 3-kinase (PI-3K), Ras, and the epidermal growth factor receptor with specific inhibitors had no effect on induction of Ras, p21, and p27 at the messenger RNA level in decorin synthesizing SVZ and U-87 cells
Calvo et al., Ann Oncol 2007 (Carcinoma, Squamous Cell...) : Nevertheless, erlotinib inhibited p-EGFR in HNSCC tumors, which appeared associated to clinical benefit, and induced p27 in biopsies of normal skin