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IL4 — IL8

Text-mined interactions from Literome

Denizot et al., Biochim Biophys Acta 1999 : Interleukin-4 (IL-4) , but not IL-10, regulates the synthesis of IL-6, IL-8 and leukemia inhibitory factor by human bone marrow stromal cells ... IL-4 has no effect on the serum induced IL-8 synthesis by marrow stromal cells, but stimulates their cytokine induced IL-8 production
Larsson et al., Br J Pharmacol 1999 : IL-2 and IL-4 counteract budesonide inhibition of GM-CSF and IL-10, but not of IL-8 , IL-12 or TNF-alpha production by human mononuclear blood cells
Stríz et al., Inflammation 1999 : The present study was designed to explore the role of the Th2 cytokine IL-4 and the functionally related interleukins IL-10, and IL-13 on the regulation of IL-8 release by HBECs ... We conclude from our study that IL-4 directly induces IL-8 release from HBECs and amplifies the release of IL-8 in response to TNF alpha
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4 , tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations ... Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4 , tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Trindade et al., J Orthop Res 1999 : Interleukin-4 inhibits granulocyte-macrophage colony stimulating factor, interleukin-6 , and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro ... Interleukin-4 inhibited the expression of granulocyte-macrophage colony stimulating factor, interleukin-6 , and tumor necrosis factor-alpha at 48 hours in a dose dependent manner
Bonecchi et al., J Immunol 2000 (Dermatitis, Atopic...) : Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
Tachimoto et al., J Allergy Clin Immunol 2000 : IL-4 profoundly enhanced FcepsilonRI mediated production of macrophage inflammatory protein (MIP) 1alpha, IL-8 , and GM-CSF ... For example, the enhancement by IL-4 ( 10 ng/mL ) of the production of MIP-1alpha, IL-8 , and GM-CSF was 25-, 7-, and 90-fold, respectively, after 6 hours
Roy et al., Surgery 2000 : Interleukin-4 regulates macrophage interleukin-12 protein synthesis through a c-fos mediated mechanism
Nasu et al., Mol Hum Reprod 2001 : It is suggested that IL-4 secreted by the maternal decidual tissue as well as by the developing embryo may stimulate the production of IL-6, IL-8 , MCP-1, and M-CSF by ESC
Giustizieri et al., J Allergy Clin Immunol 2001 (Dermatitis, Atopic...) : IL-4 weakly induced IP-10, RANTES, and IL-8 but not MCP-1
Yoshida et al., Invest Ophthalmol Vis Sci 2001 : IL-4 and -13, but not IL-10, enhanced constitutive and TNF-alpha induced HRPE IL-8 and MCP-1 secretion ... IL-4 also enhanced IL-1beta induced HRPE IL-8 ... IL-8 secretion by HRPE cell-monocyte cocultures was inhibited by IL-4 , -10, and -13, whereas MCP-1 was inhibited only by IL-10
Lottaz et al., J Invest Dermatol 2001 : We hypothesize that inhibition of this pathway prevents secretion of interleukin-1, thereby downregulating interleukin-1 dependent autocrine induction of interleukin-8
Kohda et al., J Dermatol Sci 2002 : These results suggest that the histamine induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4
Bonder et al., Cytokine 2002 : While IL-4 can suppress LPS induced interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Thomas et al., Pediatr Res 2002 : IL-4 caused modest inhibition and IL-10 and IL-13 caused no inhibition of IL-8 secretion in all groups
Prause et al., Eur J Pharmacol 2003 : Pharmacological modulation of interleukin-17 induced GCP-2-, GRO-alpha- and interleukin-8 release in human bronchial epithelial cells ... We found that interleukin-17 ( 1-1000 ng/ml ) increased the release of GCP-2, GRO-alpha and interleukin-8 in a concentration dependent manner
Waehre et al., J Am Coll Cardiol 2003 (Coronary Artery Disease) : Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy reduced the spontaneous release of IL-8 and MIP-1alpha from PBMCs in CAD patients
Wright et al., J Clin Immunol 2003 (Osteomyelitis...) : We investigated the potential down-regulators of chemokine secretion IL-4 , IL-10, IL-13, dexamethasone, and PGE2, IL-10 and IL-13 down-regulate M. tuberculosis induced IL-8 , IP-10, RANTES, and MCP-1 secretion from MG-63 cells by between 48 and 94 % ( P < 0.05 ) but do not inhibit chemokine gene transcription
Vittori et al., J Allergy Clin Immunol 1992 : Protective effect of nedocromil sodium on the interleukin-1 induced production of interleukin-8 in human bronchial epithelial cells
Uchiyama et al., Am J Obstet Gynecol 1992 : These results indicate that interleukin-8-like chemotactic factor participates in the cervical ripening at term pregnancy and that the production of this factor is controlled effectively by interleukin-1
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Rollier et al., J Virol 2004 (Hepatitis C, Chronic) : Immunization induced antibodies, peptide-specific gamma interferon ( IFN-gamma ), protein-specific lymphoproliferative responses, IFN-gamma, interleukin-2 (IL-2), and IL-4 T-helper responses in both vaccinees
Wuyts et al., J Heart Lung Transplant 2004 : N-acetylcysteine inhibits interleukin-17 induced interleukin-8 production from human airway smooth muscle cells : a possible role for anti-oxidative treatment in chronic lung rejection ?
Raes et al., J Leukoc Biol 2005 (Asthma...) : In addition, we demonstrate that in vitro, interleukin-4 (IL-4) and IL-13 up-regulate mMGL1 and mMGL2 expression and that in vivo, induction of mMGL1 and mMGL2 is dependent on IL-4 receptor signaling
Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Gómez-Quiroz et al., Liver Int 2005 (Carcinoma, Hepatocellular...) : The purpose of this work was to study the regulation of IL-8 by IL-10 and IL-4 in HepG2 cells treated with acetaldehyde ( Ac ) ... While the present findings demonstrate the anti-inflammatory role of IL-4 in preventing the expression of IL-8 by Ac, the regulation of chemokines by anti-inflammatory cytokines is complex and depends on the cellular lineage
Hirota et al., Rheumatol Int 1992 : Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor
Raingeaud et al., FEBS Lett 2005 : IL-4 regulation of TNFalpha induced IL-8 expression is cell-type specific ... Moreover, overexpression of either the endogenous JAK inhibitor SOCS-1 or a dominant negative form of the STAT6 transcription factor ( STAT6DeltaC ) interferes with the IL-4 inhibitory effect on IL-8 promoter ... Overall our results suggest that IL-4 regulates TNFalpha induced IL-8 expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors
Bouchelouche et al., J Urol 2006 : Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha
Hashmi et al., Coron Artery Dis 2006 (Angina, Unstable) : Role of interleukin-17 and interleukin-17 induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease
Marie et al., Mediators Inflamm 1996 : LPS induced cell associated IL-8 , detected in the PMN cultures, could be marginally inhibited by IL-4 and IL-10
Hedges et al., Int J Antimicrob Agents 1994 : Interleukin-4 induced epithelial cell IL-6 and IL-8 production ; gamma-interferon only induced IL-6 production
Darbonne et al., J Clin Invest 1991 : Their binding of IL-8 is rapidly reversible and does not result in receptor internalization, although bound IL-8 is resistant to extraction by pH 3 buffer at 5 degrees C. 125I-IL-8 binding to red cells was not inhibited by epidermal growth factor or interleukin 1, but was inhibited by monocyte chemotactic peptide-1, which is not a neutrophil chemotaxin, but is a member of the same family of polypeptides as IL-8
Larsen et al., Biochem Biophys Res Commun 1991 : 1,25 ( OH ) 2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production
Hua et al., Molecular oral microbiology 2010 (Periodontal Diseases) : Furthermore, as little as 2 µg ml(-1) mPE was sufficient to inhibit interleukin-1ß induced secretion of interleukin-8 in both gingival epithelial cells and THP-1 cells
Vindeløv et al., Growth Horm IGF Res 2011 (Adenoma...) : Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1ß and inhibited by growth hormone releasing hormone and somatostatin
Strieter et al., Am J Respir Cell Mol Biol 1990 : The induction of AMO derived IL-8 by tumor necrosis factor (TNF), lipopolysaccharide (LPS), and interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent
Standiford et al., J Immunol 1990 : IL-4 inhibits the expression of IL-8 from stimulated human monocytes ... IL-4 suppressed IL-8 production from stimulated monocytes in a dose dependent fashion, with partial suppression observed at IL-4 concentrations as low as 10 pg/ml ... The IL-4 induced inhibition of IL-8 mRNA expression was dependent on protein synthesis, as the suppressive effects of IL-4 were significantly negated by the addition of cycloheximide
Xing et al., Chin Med J (Engl) 2011 (Alzheimer Disease) : Ex vivo cultured splenocytes isolated from mice immunized with p ( Aß ( 3-10 ) ) ( 10 ) -CpG exhibited high interleukin-4 response and low interleukin-? ( IFN-? ) response
Standiford et al., Biochem Biophys Res Commun 1990 : In this manuscript, we describe the suppression of IL-8 gene expression from stimulated monocytes by IL-4, while IL-4 had no suppressive effects on IL-8 gene expression from stimulated fibroblasts and endothelial cells
Uchiyama et al., Journal of cardiothoracic surgery 2012 : Proliferation of splenocytes, interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of IL-4 and IL-10 from opera exposed transplant recipients increased compared to that from splenocytes of untreated recipients
Weiss et al., Eur J Immunol 1989 : Human T cells and interleukin 4 inhibit the release of interleukin 1 induced by lipopolysaccharide in serum-free cultures of autologous monocytes
Hurme et al., Biochem Biophys Res Commun 1988 : Interleukin-4 inhibits interleukin-1 synthesis by a posttranscriptional mechanism ... Interleukin-4 had a clear dose dependent suppressive effect on the interleukin-1 synthesis
De Beaux et al., J Interferon Cytokine Res 1995 : Interleukin-4 and interleukin-10 increase endotoxin stimulated human umbilical vein endothelial cell interleukin-8 release ... The aim of this study was to determine the effect of interleukin-4 (IL-4) and interleukin-10 (IL-10) on interleukin-8 (IL-8) release from endothelial cells ... IL-8 release in response to IL-4 or IL-10 plateaued above 5 and 50 pg/ml, respectively
Buckley et al., Immunology 1995 (Leukemia, Experimental) : IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line ... We conclude that IL-4 alone is a weak activator of IL-3 and IL-8 gene expression in mast cells, but is able to enhance activation signals in stimulated mast cells leading to transcription and secretion of these two cytokines
Zhou et al., J Leukoc Biol 1994 (Inflammation) : Interleukin-4 , when added together with bacterial lipopolysaccharide (LPS), suppressed LPS induced increases in mRNA levels of IL-1 alpha, IL-1 beta, IL-8 , and TNF-alpha in alveolar macrophages
Leonard et al., Adv Exp Med Biol 1993 : IL-4 inhibited LPS induced secretion of both MCP-1 and NAP-1
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Seitz et al., J Immunol 1994 (Arthritis, Rheumatoid...) : The constitutive or cytokine stimulated release of IL-8 was inhibited by IFN-gamma, but not by IL-4
Schuerer-Maly et al., Immunology 1994 : IL-4 , IL-10 and transforming growth factor-beta ( TGF-beta ), which can down-regulate IL-8 production in macrophages, had no effect on IL-8 generation by our cell lines
Miossec et al., Rev Rhum Ed Fr 1993 (Arthritis, Rheumatoid...) : Since IL4 inhibits the production of proinflammatory cytokines such as IL1, IL6, TNF alpha and IL8 , we hypothesized that a deficit in IL4 production might be related to the pathogenesis of rheumatoid arthritis
Lin et al., J Biol Chem 1994 : The ability of LPS to induce IL-8 expression was suppressed by recombinant human IL-4 and dexamethasone in a concentration dependent manner
Sugiyama et al., J Rheumatol 1995 (Arthritis, Rheumatoid) : IL-4 alone inhibited the production of IL-1 beta, IL-6, and IL-8 by 32, 35, and 50 %, respectively
Gesser et al., J Leukoc Biol 1996 : IL-8 induces T cell chemotaxis, suppresses IL-4 , and up-regulates IL-8 production by CD4+ T cells ... De novo synthesis of IL-4 from CD4+ T cells cultured for 3 days was also evaluated by use of detection of [ 35S ] methionine incorporation, as visualized by autoradiography of 2-D gels, and showed that IL-8 suppressed IL-4 production ... The regulatory effect of IL-8 on IL-4 production was also indicated by the fact that addition of a neutralizing monoclonal anti-IL-8 antibody ( WS.4 ) enhanced the spontaneous IL-4 production when added to the culture of CD4+ T cells, thereby probably inactivating the effect of IL-8 originating from the cultured T cells
Benveniste et al., Proc Natl Acad Sci U S A 1996 (Acute Disease...) : Comparative interleukin ( IL-2 ) /interferon IFN-gamma and IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Salvucci et al., Eur J Immunol 1996 : Differential regulation of interleukin-12- and interleukin-15 induced natural killer cell activation by interleukin-4
Gollob et al., Eur J Immunol 1997 : Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Badolato et al., Blood 1997 (Inflammation) : In addition, IL-8 and MCP-1 induction by IL-15 is differently regulated by interferon-gamma (IFN-gamma) and IL-4 ... IFN-gamma inhibited IL-15 induced IL-8 secretion, but synergized with IL-15 in MCP-1 induction ; whereas IL-4 inhibited both IL-8 and MCP-1 induction by IL-15
Rougier et al., Cytokine 1998 : G-CSF stimulated and IL-4 inhibited IL-8 production in 10 % FCS
Krakauer et al., J Infect Dis 1998 : Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and independent of interleukin-1 and tumor necrosis factor-alpha
Aihara et al., Dig Dis Sci 1998 : Live H. pylori induced production of many cytokines, such as IL-1beta, IL-10, IL-8 , IFN-gamma, and TNF-alpha, whereas we could not detect IL-2 or IL-4