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PDK1 — PIK3R1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lu et al., Mol Cancer Res 2010
(Carcinoma...) :
These studies show that
PDK1 plays a pivotal role in MAPK and
PI3K signaling in tumor cells
Mason et al., IDrugs 2010
(Neoplasms) :
This conference report highlights selected presentations on preclinical data on the novel pan-PI3K pyrimidine derived inhibitor BKM-120 ( Novartis AG ), the dual
inhibition of
mTOR/PI3K in NSCLC by PF-4691502 ( Pfizer Inc ), the small-molecule
PDK-1 inhibitors PF-05177624 and PF-05197281 ( both Pfizer ) and the ability of RO-5323441 ( F Hoffmann-La Roche Ltd/ThromboGenics NV/BioInvent International AB ) to block tumor growth in vivo