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HGF — SMAD3

Text-mined interactions from Literome

Yang et al., Am J Pathol 2003 (Fibrosis) : To decipher the mechanism underlying HGF antagonizing TGF-beta1 's action, we examined the effects of HGF on TGF-beta1 mediated Smad signaling ... HGF neither inhibited Smad-2/3 phosphorylation and their association with Smad-4 induced by TGF-beta1, nor significantly affected inhibitory Smad-6 and -7 expression and cellular abundance of Smad transcriptional co-repressors in NRK-49F cells ... In vivo, HGF selectively blocked Smad-2/3 nuclear accumulation in renal interstitial cells in the fibrotic kidneys induced by unilateral ureteral obstruction
Liu et al., American journal of physiology. Renal physiology 2004 (Disease Progression...) : In interstitial fibroblasts, HGF blocks activated Smad-2/3 nuclear translocation, whereas it specifically upregulates the expression of the Smad transcriptional corepressor SnoN in tubular epithelial cells
de Caestecker et al., Genes Dev 1998 : We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase ( s ) downstream of MEK1