Shyu et al., Eur J Heart Fail 2010
(MAP Kinase Signaling System) :
Phosphatidylinositol-3 kinase (PI-3) and Akt inhibitors ( wortmannin and Akt inhibitor X ) completely attenuated the endoglin protein expression induced by TGF-beta1
Lee et al., Mol Biol Cell 2012
:
We demonstrate that endoglin interacts with the PI3K subunits p110a and p85 via GIPC to recruit and activate PI3K and Akt at the cell membrane
Pericacho et al., PloS one 2013
(Cicatrix) :
We demonstrate that endoglin expression regulates Akt phosphorylation and that PI3K inhibition abolishes the differences in proliferation between endoglin haploinsufficient and control cells