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AKT2 — TPO

Text-mined interactions from Literome

Miyakawa et al., J Biol Chem 2001 : TPO induced Akt phosphorylation was significantly decreased in transfected cells suggesting an important role of SHP2 in the complex to enhance PI3K activity
Tong et al., J Exp Med 2004 : The absence of Lnk caused enhanced and prolonged Tpo induction of STAT3, STAT5, Akt , and MAPK signaling pathways in CD41+ megakaryocytes
Romanelli et al., Am J Physiol Gastrointest Liver Physiol 2006 (Hepatoblastoma) : TPO also activated phosphatidylinositol 3-kinase (PI3K) and the downstream kinase Akt in a time dependent manner
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007 : Bcl-xL protein is expressed throughout megakaryopoiesis until platelets are produced, and its expression level is at least in part post-translationally regulated through TPO mediated Akt activation
Hitchcock et al., Blood 2008 (MAP Kinase Signaling System...) : In contrast, Tpo mediated activation of positive megakaryopoiesis regulators such as ERK1/2 and AKT is increased in FAK-null megakaryocytes, providing a plausible explanation for the observed increases in megakaryopoiesis in these mice
Hitchcock et al., Blood 2008 : After Tpo stimulation, internalization was greatly reduced in c-Mpl Y ( 78 ) F and c-Mpl Y ( 8+78 ) F, and these cell lines also exhibited increased proliferation and increased strength and duration of Jak2, STAT5, AKT , and ERK1/2 activation in response to Tpo
Soda et al., Cell Signal 2008 : Previously we and others have shown that TPO activates PI3K and Akt and that this pathway is important for megakaryocyte growth ... We conclude that GSK-3beta is phosphorylated and inhibited by TPO induced Akt , promoting survival and proliferation in megakaryocytic cells through a pathway that does not involve beta-catenin
Erhardt et al., Exp Hematol 2009 (Thrombocytopenia) : In signal transduction studies of washed human platelets, eltrombopag induced the phosphorylation signal transducers and activators of transcription ( STAT ) proteins with no phosphorylation of Akt, whereas recombinant human TPO ( rhTPO ) induced the phosphorylation of Akt as well as STAT-1, -3, and -5
Tashiro et al., Stem Cells Dev 2012 : Furthermore, Lnk inhibition by the overexpression of the DN-Lnk gene augmented the TPO induced phosphorylation of Erk1/2 and Akt , indicating the enhanced sensitivity to TPO