◀ Back to SMAD3
ESR1 — SMAD3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD3/SMAD4/ER alpha complex (SMAD3-SMAD4-ESR1)
→
SMAD3/SMAD4/SP1 complex (SMAD3-SMAD4-SP1)
(transcription, inhibits)
Poncelet et al., J Biol Chem 2001*, Matsuda et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
ER alpha (ESR1)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, collaborate)
Matsuda et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
ER alpha (ESR1)
→
SMAD3/SMAD4/ER alpha complex (SMAD3-SMAD4-ESR1)
(modification, collaborate)
Matsuda et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
SMAD3/SMAD4/ER alpha complex (SMAD3-SMAD4-ESR1)
(modification, collaborate)
Matsuda et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cherlet et al., Mol Cell Biochem 2007
(Breast Neoplasms) :
Transient transfection of Cos1 cells with p3TP-lux, demonstrate that
ERalpha and ERbeta ( 1 )
repress Smad3 transcriptional activity in an estradiol dependent manner and that this effect is inhibited by antiestrogen treatment
Ito et al., J Biol Chem 2010
(Breast Neoplasms...) :
ERalpha mediated reductions in
Smad levels did not require the DNA binding ability of ERalpha, implying that ERalpha opposes the effects of TGF-beta via a novel non-genomic mechanism ... Our analysis revealed that
ERalpha formed a protein complex with Smad and the ubiquitin ligase Smurf, and
enhanced Smad ubiquitination and subsequent degradation in an estrogen dependent manner