Kim et al., Biochem Biophys Res Commun 2001
:
In the cell death paradigm induced by MPP ( + ), overexpression of Bcl-2 in MN9D cells ( MN9D/Bcl-2 ) significantly blocked MPP ( + ) -induced downregulation of COX III and ATPase 6 transcripts
Itano et al., Brain Res 1995
(Neuroblastoma) :
1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms ... These results also suggest that the mechanism by which MPP+ increases the Bcl-2 protein level is different from that of MPP ( + ) -induced cell death