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CSF2 — TLR6

Text-mined interactions from Literome

Krutzik et al., Nat Med 2005 (Leprosy) : CD1b+ dendritic cells were expanded by TLR mediated upregulation of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009 (Crohn Disease) : In CD patients, TLR induced GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Fukuzono et al., Arch Biochem Biophys 2010 : G-CSF and GM-CSF did not affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3