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SMAD5 — TGFB2
Text-mined interactions from Literome
Saika et al., Exp Eye Res 2001
:
Finally, we examined whether exogenous
TGFbeta2 induced
Smad nuclear translocation in murine lenses in organ culture
Chipuk et al., J Biol Chem 2002
(Adenocarcinoma...) :
In the prostate, androgens negatively regulate the expression of
transforming growth factor-beta ( TGF-beta ) ligands and receptors and
Smad activation through unknown mechanisms
Prokova et al., J Biol Chem 2002
(Cell Transformation, Neoplastic) :
Inhibition of
transforming growth factor beta signaling and
Smad dependent
activation of transcription by the Latent Membrane Protein 1 of Epstein-Barr virus
Chai et al., J Biol Chem 2003
:
The
Smad family of proteins
mediates transforming growth factor-beta signaling from cell membrane to the nucleus
Mori et al., Int J Cancer 2003
(Carcinoma, Hepatocellular...) :
Repression of
Smad dependent
transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
Wang et al., J Biol Chem 2005
:
Recently, we found that enforced expression of ARA55 inhibits
transforming growth factor-beta mediated up-regulation of
Smad binding element-luciferase reporter activity in NRP-154 and NRP-152 rat prostate and LNCaP human prostate cell lines
Itoh et al., Exp Eye Res 2007
:
In the luciferase assay using a mutation construct of the Smad binding site in COL1A2 promoter ( Smad-mut/Luc ), the treatment with simvastatin and Y27632 significantly reduced
TGF-beta2 induction of
Smad-mut/Luc promoter activity
Buijs et al., Am J Pathol 2007
(Bone Neoplasms...) :
Moreover, BMP7 induced activation of nuclear
Smad1/4/5 signaling transduced via BMP type I receptors was synergistically stimulated in the
presence of
transforming growth factor beta , a growth factor that is enriched in the bone microenvironment
Li et al., Circ Res 2008
:
Atrial natriuretic peptide inhibits
transforming growth factor beta induced
Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
Suenaga et al., FEBS Lett 2008
:
This study reports that resveratrol increased transcription of the
TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and
activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line
Horie et al., J Lipid Res 2008
:
One of the genes identified was TG-interacting factor (TGIF), a DNA binding homeodomain protein that has been demonstrated to suppress
Smad mediated activation of
transforming growth factor beta ( TGF-beta ) -regulated transcription
Lee et al., J Biol Chem 2008
:
Endoglin promotes
transforming growth factor beta mediated
Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC
Truty et al., J Biol Chem 2009
:
The
role of
non-Smad proteins in the regulation of
transforming growth factor-beta ( TGFbeta ) signaling is an emerging line of active investigation
Eloy et al., Virchows Arch 2012
(Carcinoma...) :
It was also shown that
transforming growth factor beta ( TGF-beta )
/Smad dependent pathway activity is associated with local invasion, nodal metastatization and BRAF mutated PTCs