Mandal et al., Endocrinology 2009
:
Inhibition of PI3K/Akt signaling blocked the binding of Smads 1/5 to the CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Perron et al., Neural development 2011
:
BMP6 , which evokes neural induction but does not have orienting activity, activates Smad signaling but does not stimulate PI3K Ueki et al., Glia 2013
:
Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation