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DOCK2 — RAC2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
DOCK2
—
RAC2
(direct interaction, pull down)
Nishihara et al., Biochim Biophys Acta 1999*
-
IRef Dip Interaction:
Complex of ELMO1-DOCK2-RAC2
(anti tag coimmunoprecipitation)
Janardhan et al., PLoS Biol 2004*
-
IRef Dip Interaction:
DOCK2
—
RAC2
(physical association, pull down)
Janardhan et al., PLoS Biol 2004*
-
IRef Dip Interaction:
Complex of DOCK2-DOCK2-DOCK2-RAC2-RAC2-RAC2-ELMO1-ELMO1-ELMO1
(anti tag coimmunoprecipitation)
Janardhan et al., PLoS Biol 2004*
-
IRef Dip Interaction:
Complex of ELMO1-DOCK2-RAC2
(pull down)
Janardhan et al., PLoS Biol 2004*
-
IRef Hprd Interaction:
DOCK2
—
RAC2
(in vitro)
Nishihara et al., Biochim Biophys Acta 1999*
-
IRef Ophid Interaction:
DOCK2
—
RAC2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Sanui et al., Immunity 2003
:
We show here that
DOCK2 is
essential for TCR mediated
Rac activation and immunological synapse formation
Jiang et al., J Exp Med 2005
:
In addition, we found that
DOCK2 is
critical for CD28 mediated
Rac activation and is required for the full activation of alloreactive T cells
Kunisaki et al., J Cell Biol 2006
:
DOCK2 is a
Rac activator that regulates motility and polarity during neutrophil chemotaxis
Nishikimi et al., Science 2009
:
In neutrophils,
Rac activation is primarily
mediated by
DOCK2 , an atypical guanine nucleotide exchange factor
Namekata et al., Proc Natl Acad Sci U S A 2010
:
BDNF induces axonal sprouting through
Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
:
Multiple factors confer specific Cdc42 and
Rac protein
activation by
dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Ippagunta et al., Nat Immunol 2011
:
Thus, ASC shapes adaptive immunity independently of inflammasomes by modulating
Dock2 dependent
Rac activation and actin polymerization in DCs and lymphocytes