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IL18 — IL1B
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Companjen et al., Eur Cytokine Netw 2000
:
Finally, our results show that stimulation of the keratinocyte cell line HaCaT with PMA LPS or
IL-1beta , does not significantly
affect intracellular or released ( pro )
IL-18 levels
Jablonska et al., Immunol Invest 2001
:
Role of
IL-18 in the secretion of
Il-1beta , sIL-1RII, and IL-1Ra by human neutrophils ... In the present study we investigated the
effect of
IL- 18 on the production of
IL-1beta , IL-1Ra and sIL-1RII by human neutrophils
Lottaz et al., J Invest Dermatol 2001
:
In interleukin-1beta transfected human dermal fibroblasts,
interleukin-8 was
induced through an autocrine activity of
interleukin-1beta
Veenstra et al., J Immunol 2002
(Neoplasms) :
In contrast, IL-1alpha,
IL-1beta , TNF-alpha, IFN-gamma-inducible protein-10, and Th2 cytokines such as IL-4 and IL-10 did not
induce IL-18BPa
Jabłońska et al., Arch Immunol Ther Exp (Warsz) 2002
:
Effect of
IL-18 on
IL-1beta and sIL-1RII production by human neutrophils ... In the present study we investigated the
effect of
interleukin 18 (IL-18) on the production of
IL-1beta and soluble IL-1 receptor II ( sIL-1RII ) by human neutrophils ... The results obtained indicate that recombinant human
IL-18 ( rhIL-18 )
induces IL-1beta and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood
Splíchal et al., Vet Res 2002
(Salmonella Infections, Animal) :
In the ileum, IFN-gamma, TNF-alpha, and
IL-1beta were
induced mainly by the virulent strain, whereas
IL-18 was induced in highest quantity by non-virulent Salmonella
Joshi et al., Infect Immun 2002
(Disease Susceptibility...) :
At 75 micro g, LPS
induced a transient increase in
IL-1beta and IL-18 levels in serum, whereas at 500 micro g it induced a 1.5-fold-higher
IL-18 level in serum, which increased till death
Hassanain et al., Neuroscience 2003
:
In particular,
interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of
interleukin-1beta on this form of emotional behavior are
mediated via a 5-HT2 receptor mechanism
Fujiwara et al., Cancer Res 1992
:
Specific inhibition of
interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory
role of
interleukin 1 in the generation of lymphokine activated killer cells
Dai et al., Arthritis Rheum 2004
(Arthritis, Rheumatoid) :
Interleukin-18 enhances monocyte tumor necrosis factor alpha and
interleukin-1beta production induced by direct contact with T lymphocytes : implications in rheumatoid arthritis ...
IL-18 dose-dependently
enhanced the production of
IL-1beta and TNFalpha, but not IL-10, by monocytes following contact with RA synovial T cells or PHA prestimulated T cells
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
Flow cytometric analysis showed that
IL1beta , tumour necrosis factor alpha, and IL18 up
regulated IL18Ralpha expression levels
Luz et al., Neuropeptides 2006
(Dehydration...) :
These results suggest that the central
activation of
interleukin-1 receptors by
IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Bernardino et al., J Neurochem 2008
(Encephalitis...) :
Potentiation of AMPA toxicity was prevented when
IL-1beta production or its receptor signaling were
blocked by an inhibitor of
interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Haber et al., Exp Parasitol 2009
(Hyperalgesia...) :
Leishmania major
: interleukin-13 increases the infection induced hyperalgesia and the levels of
interleukin-1beta and interleukin-12 in rats
Nold-Petry et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
In addition, we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and
IL-12/IL-18 induced
IL-1beta , IL-6, interferon-gamma, and CD40L
Elias et al., Chest 1990
(Pneumonia...) :
To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the
effects of recombinant
interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production,
interleukin-1-beta production, and interleukin-6 production
Rodriguez-Cimadevilla et al., Blood 1990
(Leukemia, Myeloid, Acute) :
Coordinate secretion of
interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia :
role of
interleukin-1 as an endogenous inducer
Mauviel et al., Biochem Biophys Res Commun 1988
:
The ability of the two forms of
interleukin-1 , IL-1 alpha and IL-1 beta, to
induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Yoza et al., J Biol Chem 1996
:
In human monocytes,
interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a
result of increased transcription of the
interleukin 1beta gene
Kang et al., Spine (Phila Pa 1976) 1997
(Intervertebral Disc Displacement) :
Normal and herniated human intervertebral disc specimens were cultured to study the
effects of
interleukin-1 beta on the production of nitric oxide,
interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide,
interleukin-6 , and prostaglandin E2 in
response to
interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997
(Glioblastoma) :
In human glioblastoma A172 cells,
interleukin-6 (IL-6) production was
induced by
interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Puren et al., J Clin Invest 1998
:
Interleukin-18 ( IFNgamma inducing factor )
induces IL-8 and
IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells ... In purified CD14+ cells but not CD3+/CD4+,
IL-18 induced gene expression and synthesis of IL-8 and
IL-1beta