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TLR4 — TSLP
Text-mined interactions from Literome
Ozawa et al., Mod Rheumatol 2007
(Arthritis, Rheumatoid...) :
This study investigated whether
Toll-like receptor ( TLR ) ligands, lipopolysaccharide (LPS) and poly-IC
affect TSLP production in synovial fibroblasts
Hammad et al., Nat Med 2009
(Asthma...) :
TLR4 triggering on structural cells
caused production of the innate proallergic cytokines
thymic stromal lymphopoietin , granulocyte-macrophage colony stimulating factor, interleukin-25 and interleukin-33
Kashyap et al., J Immunol 2011
:
DCs are important primary targets of TSLP, and we unexpectedly demonstrated that DCs also produce
TSLP in
response to
TLR stimulation and that this is augmented by IL-4
Li et al., J Allergy Clin Immunol 2011
(Inflammation...) :
For the first time, we have shown that SRW pollen, acting as a functional TLR4 agonist, initiates
TLR4 dependent
TSLP/OX40L/OX40 signaling, which triggers T ( H ) 2-dominant allergic inflammation