Gene interactions and pathways from curated databases and text-mining

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TLR4 — TSLP

Text-mined interactions from Literome

Ozawa et al., Mod Rheumatol 2007 (Arthritis, Rheumatoid...) : This study investigated whether Toll-like receptor ( TLR ) ligands, lipopolysaccharide (LPS) and poly-IC affect TSLP production in synovial fibroblasts
Hammad et al., Nat Med 2009 (Asthma...) : TLR4 triggering on structural cells caused production of the innate proallergic cytokines thymic stromal lymphopoietin , granulocyte-macrophage colony stimulating factor, interleukin-25 and interleukin-33
Kashyap et al., J Immunol 2011 : DCs are important primary targets of TSLP, and we unexpectedly demonstrated that DCs also produce TSLP in response to TLR stimulation and that this is augmented by IL-4
Li et al., J Allergy Clin Immunol 2011 (Inflammation...) : For the first time, we have shown that SRW pollen, acting as a functional TLR4 agonist, initiates TLR4 dependent TSLP/OX40L/OX40 signaling, which triggers T ( H ) 2-dominant allergic inflammation