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PAPPA — TNF

Text-mined interactions from Literome

Conover et al., Bone 2004 : Tumor necrosis factor alpha (TNFalpha) , IL-1beta, and IL-4 also increased PAPP-A expression 3- to 4-fold
Resch et al., Endocrinology 2006 (Second Messenger Systems) : The JNK inhibitor, SP600125, had no effect on IL-1beta- or TNFalpha stimulated PAPP-A mRNA expression
Conover et al., Am J Physiol Cell Physiol 2006 : Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta stimulated PAPP-A gene expression in a time- and dose dependent manner ... Our finding that PAPP-A gene expression in hCASMC is stimulated by TNF-alpha and IL-1beta suggests a mechanism for the regulation of PAPP-A in response to vascular injury that may contribute to the enhanced IGF-I bioactivity in intimal hyperplasia and atherosclerotic plaque development
Li et al., Zhonghua Xin Xue Guan Bing Za Zhi 2006 : We investigated the effects of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-alpha) on PAPP-A mRNA expression in monocytes ... PAPP-A mRNA expression could be stimulated by CRP and TNF-alpha in human peripheral blood monocytes which might be responsible for the increased serum PAPP-A level in patients with acute coronary syndromes
Conover et al., Growth Horm IGF Res 2008 : Stimulation of PAPP-A expression by TNF-alpha was associated with significantly increased VCAM, ICAM, and MCP-1 expression but without major changes in other IGF system components ... The anti-oxidant, N-acetyl cysteine, inhibited TNF-alpha induced PAPP-A expression without altering the induction in VCAM, ICAM, and MCP-1
Deb et al., Growth Horm IGF Res 2012 : Although TNF-a induced PAPP-A expression in skeletal myoblast culture and its expression increased upon injury, abrogation of TNF-a signaling in TNF-a receptor knockout mice had no impact on the extent of injury induction of PAPP-A