Cao et al., J Immunol 2004
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The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells
Márquez-Marín et al., Reumatol Clin 2007
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It has been demonstrated that Fasmediated apoptosis participates in the physiopathology of lupus nephritis, although it is not clear whether it contributes to the development of the tissue damage.Since YY-1 down regulates Fas in cancer cell lines, it is reasonable to consider that this transcription factor may control Fas expression in lupus nephritis