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CDC42 — PLCG1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of CDC42 activity: CDC42/GDP complex (CDC42) → PLCgamma1/betaPIX/GIT1 complex (PLCG1-ARHGEF7-GIT1) (modification, collaborate)
  Jones et al., Mol Cell Biol 2007*
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Papakonstanti et al., Mol Biol Cell 2004 : Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42 induced phospholipase C-gamma1 activation and actin filament redistribution
Piechulek et al., J Biol Chem 2005 : PLCgamma(2), but not PLCgamma(1) , was markedly activated in intact cells by constitutively active Rac1 ( G12V ), Rac2 ( G12V ), and Rac3 ( G12V ) but not by Cdc42 ( G12V ) and RhoA ( G14V )
Jones et al., Mol Cell Biol 2007 : Furthermore, siRNA depletion of PLCgamma1 , beta-Pix, or GIT1 inhibited Cdc42 and Rac1 activation, while constitutively active forms of Cdc42 or Rac1, but not RhoA, were able to rescue the elongation of these cells ... As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1