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Ohyama et al., Biol Pharm Bull 2003 : Western blotting analysis showed that in Vitex extract treated KATO-III cells, the presence of NAC also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8 and -9
Hirano et al., Toxicology 2003 : The transcription levels of HO-1 and HSP72 in OE-DEP- and OE-UFP exposed cells were also reduced by NAC
Hirano et al., Arch Toxicol 2003 : N-acetyl- l-cysteine (NAC) reduced both the cytotoxicity of inorganic arsenic and the HO-1 mRNA level, and buthionine sulfoximine enhanced cytotoxicity of inorganic arsenic
Liu et al., Life Sci 2004 (MAP Kinase Signaling System) : 15d-PGJ ( 2 ) significantly decreased the intracellular level of reduced glutathione ; and the thiol antioxidant, N-acetyl-L-cysteine (NAC) , and the thiol reducing agent, dithiothreitol ( DTT ), inhibited the induction of HO-1 by 15d-PGJ ( 2 )
Hirano et al., Arch Toxicol 2005 : N-Acetyl-L-cysteine (NAC) reduced the cytotoxicity and induction of heme oxygenase-1 (HO-1) mRNA in PAO3+ exposed cells, while NAC affected neither the cytotoxicity nor the HO-1 mRNA level in PAA5+ exposed cells
Koike et al., Toxicol Appl Pharmacol 2004 : Furthermore, these effects of DEP on either HO-1 or TGM-2 were reduced by N-acetyl-l-cysteine (NAC) , thus suggesting that oxidative stress caused by this organic fraction of DEP may have induced these cellular responses
Yi et al., Brain Res 2005 (Brain Injuries...) : We have studied the temporal and spatial effects of the antioxidant N-acetylcysteine (NAC) on HO-1 levels following lateral fluid-percussion injury by immunoblotting and immunohistochemistry
Yasui et al., Biol Pharm Bull 2007 (Leukemia, Basophilic, Acute) : The effect of the antioxidant N-acetyl-L-cysteine (NAC) on HO-1 expression was also tested ... NAC attenuated the HO-1 expression in a dose dependent manner ... We showed that NAC inhibited HO-1 upregulation
Park et al., Biochimie 2010 (Colonic Neoplasms) : Rottlerin mediated HO-1 induction was abrogated in the presence of N-acetylcysteine (NAC) or glutathione ( GSH )
Forti et al., Cell Physiol Biochem 2010 : The protective effect of NAC against CdCl ( 2 ) induced MT1X, HSP70 and HMOX-1 genes, demonstrates an anti-oxidant effect of NAC in addition to Cd chelation
Rizzardini et al., Biochem J 1994 : In the absence of BSO, N-acetylcysteine (NAC) ( 1 g/kg orally ) reduced LPS induced HO-1 mRNA accumulation to one fourth ... NAC also reduced HO-1 mRNA accumulation when administered to mice in which glutathione was depleted and its synthesis blocked by BSO ( 1.6 g/kg )