Gene interactions and pathways from curated databases and text-mining

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CSRP1 — SRF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: SRF → Complex of CSRP1-SRF (directlyIncreases, CSRP1/SRF Activity)
    Evidence: there are LIM proteins (CRP1 and CRP2 that can associate with SRF in the nucleus to direct SRF-dependent gene expression

Text-mined interactions from Literome

Lilly et al., Dev Biol 2001 : Our findings provide further evidence for the existence of distinct regulatory programs within SMCs and suggest a role for SRF in the activation of the CRP1 gene
Zhang et al., J Biol Chem 2007 : In the presence of CRP4 , cGMP/PKG increased SRF- and GATA6 dependent expression of endogenous SM-specific genes in pluripotent 10T1/2 cells