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FGF2 — IL8
Text-mined interactions from Literome
Bodo et al., Eur J Cell Biol 1999
(Craniofacial Dysostosis) :
ELISA showed that
bFGF induced
interleukin secretion differed in normal and Crouzon osteoblasts
Giri et al., Am J Pathol 2001
(Prostatic Hyperplasia) :
Interleukin-8 is a paracrine
inducer of
fibroblast growth factor 2 , a stromal and epithelial growth factor in benign prostatic hyperplasia ... Therefore
IL-8 produced by prostatic epithelial cells can
induce FGF2 , a potent stromal and epithelial growth factor, and in this manner promote the abnormal proliferation of the prostatic transition zone that is critical in the pathogenesis of BPH
Castro et al., Prostate 2004
(Prostatic Hyperplasia) :
IL-8 is also present at increased levels in BPH tissues and
induces expression of
FGF2 , a potent stromal growth factor
Im et al., J Biol Chem 2007
:
bFGF stimulation of MMP-13 was
mediated at the transcriptional level and, at least in part, by stimulation of
interleukin-1 production
Ulbrich et al., J Cell Biochem 2008
:
After 24 h micro g,
bFGF elevated fibronectin, Flk-1 and Flt-1 protein, and
reduced IL-6 and
IL-8 compared with vehicle treated micro g cultures
Sandell et al., Osteoarthritis Cartilage 2008
(Arthritis) :
In the presence of IL-1beta,
FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and
IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Herseth et al., Particle and fibre toxicology 2008
:
Silica exposure induced an increase of
IL-8 release from monocytes and from pneumocytes alone, and the
FGF-2 level in the medium
increased upon silica exposure of pneumocytes
Nakayama et al., J Oral Sci 2012
:
In human osteoblast-like Saos2 cells,
FGF2 increased the expression of the osteopontin ( SPP1, 16.7-fold ),
interleukin-8 ( IL8, 6.4-fold ) and IL11 ( 4.8-fold ) genes
Chandrasekhar et al., J Cell Physiol 1989
:
Induction of
interleukin-1 receptors on chondrocytes by
fibroblast growth factor : a possible mechanism for modulation of interleukin-1 activity
Iwamoto et al., Immunol Lett 1989
:
Furthermore,
interleukin 1 (IL-1) suppressed by 50-60 % the incorporation of [ 3H ] thymidine into DNA in high density chondrocyte cultures on plastic dishes in the
presence of 10 % serum or
fibroblast growth factor , although it increased twofold this incorporation in 0.3 % serum alone
Norioka et al., Jpn J Cancer Res 1994
(Neovascularization, Pathologic) :
Interaction of
interleukin-1 and interferon-gamma on
fibroblast growth factor induced angiogenesis
Tamura et al., Endocrinology 1996
(Arthritis...) :
Nitric oxide mediates
interleukin-1 induced matrix degradation and
basic fibroblast growth factor release in cultured rabbit articular chondrocytes : a possible mechanism of pathological neovascularization in arthritis
Nakamura et al., J Hypertens 1996
:
bFGF , TGF-beta,
interleukin-1 alpha, -1 beta and -6
stimulated DNA synthesis in VSMC significantly, whereas HGF did not
Schwarz et al., Kidney Int 1997
:
Finally, unlike other mesangial growth factors
basic fibroblast growth factor (bFGF) induced MCP-1, RANTES, and
IL-8 mRNA expression, suggesting an involvement of autocrine regulation mechanisms in mesangial chemokine expression
Kumar et al., Int J Oncol 1998
:
The organization of endothelial cells to form tubes on Matrigel was
induced by
bFGF and, to a lesser extent, by VEGF/VPF and
IL-8
Presta et al., J Biol Chem 1998
:
IL-8 did not
prevent the binding of
bFGF to its tyrosine kinase FGF receptors ( FGFRs ) nor to cell surface heparan sulfate proteoglycans ( HSPGs ) ... A transient interaction of
IL-8 with the cell before the addition of the growth factor was
sufficient to prevent
bFGF activity
Sasaki et al., J Biochem 1998
:
Nitric oxide mediates
interleukin-1 induced gene expression of matrix metalloproteinases and
basic fibroblast growth factor in cultured rabbit articular chondrocytes