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CDH1 — HGF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Davies et al., Clin Cancer Res 2001
(Neoplasm Invasiveness...) :
The
effects of
HGF/SF on cell-cell dissociation, in vitro invasion, and on the expression of
E-cadherin at both protein and mRNA levels were assessed in cells whose expression of Matrilysin was altered by treatment with antisense oligonucleotide ... Both recombinant human Matrilysin ( rh-Matrilysin ) and/or
HGF/SF increased the level of soluble
E-cadherin and decreased the level of full-length ( M ( r ) 120,000 ) E-cadherin as detected by Western blotting
Shimabukuro et al., Gynecol Oncol 2001
(Adenocarcinoma...) :
To investigate the mechanism of an inductive effect of HGF/SF on the invasiveness of SKG-IIIa, we examined the
effect of
HGF/SF on the expression of intercellular adhesion molecule
E-cadherin , cell-substrate adhesion molecules CD44, alpha2beta1, and alpha6beta1, and intracellular skeleton fiber actin in SKG-IIIa in cell enzyme linked immunosorbent assay ( ELISA ) and immunofluorescence staining ... To investigate the mechanism of an inductive effect of HGF/SF on the invasiveness of SKG-IIIa, we examined the
effect of
HGF/SF on the expression of intercellular adhesion molecule
E-cadherin , cell-substrate adhesion molecules CD44, alpha2beta1, and alpha6beta1, and intracellular skeleton fiber actin in SKG-IIIa in cell enzyme linked immunosorbent assay ( ELISA ) and immunofluorescence staining
Boon et al., Br J Cancer 2005
(Cell Transformation, Neoplastic...) :
Upon
stimulation with
HGF , the expression of
E-cadherin is downregulated in wild-type MET transfected cells, whereas cells expressing mutated MET show low E-cadherin levels independent of stimulation with ligand
Han et al., Ann Surg 2005
(Carcinoma...) :
This study focused on the
role of
HGF on the expression and distribution of
E-cadherin ... Western blot analysis and invasion assay were performed to confirm the
role of
HGF on the modulation of
E-cadherin using human gastric cancer cell lines
Kim et al., Ann Surg Oncol 2007
(Adenocarcinoma...) :
Therefore, we examined how
HGF affects the expression and distribution of
E-cadherin ...
HGF decreased the expression of E-cadherin and
induced the translocation of
E-cadherin to the cytoplasm
Lee et al., Eur Surg Res 2007
(Adenocarcinoma...) :
The
effects of
HGF on the expression of
E-cadherin/beta-catenin and MMP-7 at both the protein and mRNA levels were assessed in stomach cancer cells, NUGC-3 and MKN-28, and in cells in which the expression of MMP-7 was downregulated by transfection with a MMP-7 short hairpin RNA plasmid
Hills et al., Mol Endocrinol 2010
:
Further, effects of TGF-beta1 on Snail and
E-cadherin expression were
blocked by
HGF , and inhibitory effects of C-peptide were removed by blockade of HGF activity
Hu et al., Anat Rec (Hoboken) 2010
(Ovarian Neoplasms) :
Our data indicated that
HGF leads to downregulation of
E-cadherin , beta-catenin, and caveolin-1, disassembly of cell-cell contacts, and invasion and migration enhancement in human ovarian cancer cells ... Our data indicated that
HGF leads to downregulation of
E-cadherin , beta-catenin, and caveolin-1, disassembly of cell-cell contacts, and invasion and migration enhancement in human ovarian cancer cells
Hung et al., J Agric Food Chem 2011
(Breast Neoplasms...) :
Osthole also effectively inhibited the
HGF induced decrease of
E-cadherin and increase of vimentin via down-regulation of phosphorylated Akt and mTOR
Lai et al., J Cell Sci 2012
(MAP Kinase Signaling System...) :
In particular, we found that KLF4 was upregulated by HGF in two independent epithelial cell types, HepG2 and MDCK, whereas KLF4 knockdown inhibited
HGF induced
E-cadherin suppression and cell scattering
Balkovetz et al., J Biol Chem 1997
:
Surface biotinylation experiments showed that
HGF increases apically accessible
E-cadherin