◀ Back to CDH1
CDH1 — IQGAP1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
CDC42/GTP/IQGAP1 complex (CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CDC42 signaling events:
alpha catenin (CTNNA1)
→
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
→
None
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database CDC42 signaling events:
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
RAC1/GTP/IQGAP1 complex (RAC1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
alpha catenin (CTNNA1)
→
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
→
None
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/IQGAP1/p120 catenin complex (CDH1-CTNNB1-CTNND1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
IQGAP1 (IQGAP1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fukata et al., J Biol Chem 1999
:
The coexpression of dominant active Cdc42 with IQGAP1 suppressed the dissociation of alpha-catenin from the
cadherin-catenin complex
induced by the overexpression of
IQGAP1 in L cells expressing E-cadherin ( EL cells )
Li et al., J Biol Chem 1999
:
Immunocytochemical analysis in MCF-7 ( E-cadherin positive ) and MDA-MB-231 ( E-cadherin negative ) epithelial cells revealed that
E-cadherin is
required for accumulation of
IQGAP1 at cell-cell junctions
Sugimoto et al., J Hum Genet 2001
(Stomach Neoplasms) :
IQGAP1 has been reported to encode a ras GAP related protein, and its interaction with
cadherin and/or beta-catenin
induces a dissociation of beta-catenin from the cadherin-catenin complex, one of the mechanisms for cell-cell adhesion
Noritake et al., Mol Biol Cell 2004
:
We here found that suppression of
IQGAP1 , an actin binding protein and an effector of Rac1, by small interfering RNA apparently
reduced the accumulation of actin filaments,
E-cadherin , and beta-catenin at sites of cell-cell contact in Madin-Darby canine kidney II epithelial cells under the conditions in which knockdown of Rac1 reduced them