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CBL — HGS

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HGS → CBL (increases) Stern et al., Mol Cell Biol 2007*
  Evidence: Using an HEK 293 model system, we found that ectopic expression of the protein Cbl enhances Hrs ubiquitination and increases Hrs phosphorylation following cell stimulation with EGF.
• Reactome Reaction: CBL → HGS (indirect_complex) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
• Reactome Reaction: CBL → HGS (reaction) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 143 proteins (association, anti tag coimmunoprecipitation)

Text-mined interactions from Literome

Row et al., Biochem J 2005 : Consistent with this, expression of a dominant negative form of the E3 ubiquitin ligase, c-Cbl , inhibits EGF- and HGF dependent Hrs phosphorylation
Stern et al., Mol Cell Biol 2007 : Using an HEK 293 model system, we found that ectopic expression of the protein Cbl enhances Hrs ubiquitination and increases Hrs phosphorylation following cell stimulation with EGF