Gene interactions and pathways from curated databases and text-mining

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EPHB2 — FCGR3B

Text-mined interactions from Literome

Hazan-Halevy et al., J Biol Chem 2000 : Cross linking of FcgammaRIIA or FcgammaRIIIB induces p38 mitogen activated protein ( MAP ) kinase and extracellular regulated kinase (ERK) phosphorylation
Coxon et al., J Immunol 2000 : Homotypic and heterotypic cross linking of Fc gamma RIIa and/or Fc gamma RIIIb resulted in a rapid, transient increase in ERK and p38 activity, with maximal stimulation between 1 and 3 min. Fc gamma RIIa and Fc gamma RIIIb stimulated distinct patterns of ERK and p38 activity, and heterotypic cross linking failed to stimulate synergistic activation of either ERK or p38 activity ... Our data indicate that Fc gamma RIIa and Fc gamma RIIIb independently activate ERK and p38
García-García et al., J Immunol 2009 : FcgammaRIIIB , but not FcgammaRIIA, promoted a robust increase in phosphorylated ERK in the nucleus, and also efficient phosphorylation of the NF Elk-1 ... FcgammaRIIIB induced nuclear phosphorylation of ERK , and of Elk-1, was not affected by Syk, PI3K, or MEK inhibitors ... Also, ERK , but not MEK, was constitutively present in the nucleus, and FcgammaRIIIB cross linking did not increase the levels of nuclear ERK or MEK