◀ Back to CTNNB1
BTRC — CTNNB1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CTNNB1
→
BTRC
(decreases, CTNNB1 Activity)
Evidence: beta-TRCP is a versatile F-box protein that recognizes several cell-cycle regulators EMI1-2, WEE1A and CDC25A-B in addition to its classical substrates, beta-catenin and IkappaB. In some cancers, beta-TRCP mutation or overexpression is found.
-
BioCarta wnt signaling pathway:
beta-catenin/ubiquitin complex (CTNNB1)
→
beta-catenin/beta-TRCP complex (CTNNB1-BTRC)
(protein ubiquitination, collaborate)
-
BioCarta wnt signaling pathway:
beta-catenin (CTNNB1)
→
beta-catenin/beta-TRCP complex (CTNNB1-BTRC)
(modification, collaborate)
-
BioCarta wnt signaling pathway:
beta-catenin (CTNNB1)
→
beta-TRCP (BTRC)
(modification, collaborate)
-
BioCarta wnt signaling pathway:
beta-catenin/beta-TRCP complex (CTNNB1-BTRC)
→
beta-TRCP (BTRC)
(modification, collaborate)
-
KEGG Wnt signaling pathway:
BTRC/FBXW11
→
CTNNB1
(protein-protein, ubiquination)
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
SCF complex (BTRC-SKP1-CUL1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TRRAP (TRRAP)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
SCF complex (BTRC-SKP1-CUL1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin (CTNNB1)
→
beta TrCP1 (BTRC)
(modification, collaborate)
Ougolkov et al., J Natl Cancer Inst 2004*
Evidence: sequence or structure
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin (CTNNB1)
→
beta catenin/beta TrCP1 complex (CTNNB1-BTRC)
(modification, collaborate)
Ougolkov et al., J Natl Cancer Inst 2004*
Evidence: sequence or structure
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta TrCP1 (BTRC)
→
beta catenin/beta TrCP1 complex (CTNNB1-BTRC)
(modification, collaborate)
Ougolkov et al., J Natl Cancer Inst 2004*
Evidence: sequence or structure
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin (CTNNB1)
→
beta TrCP1 (BTRC)
(modification, collaborate)
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta catenin (CTNNB1)
→
beta catenin/beta TrCP1 complex (CTNNB1-BTRC)
(modification, collaborate)
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
beta TrCP1 (BTRC)
→
beta catenin/beta TrCP1 complex (CTNNB1-BTRC)
(modification, collaborate)
-
NCI Pathway Database Degradation of beta catenin:
SCF complex (BTRC-SKP1-CUL1)
→
APC/beta catenin complex (APC-CTNNB1)
(modification, activates)
Hart et al., Curr Biol 1999, Kitagawa et al., EMBO J 1999, Winer et al., J Biol Chem 2006, Seo et al., Cell Signal 2009, Su et al., Mol Cell 2008
Evidence: assay, physical interaction
-
Reactome Reaction:
CTNNB1
→
BTRC
(indirect_complex)
Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
-
Reactome Reaction:
CTNNB1
→
BTRC
(reaction)
Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
-
Reactome Reaction:
BTRC
→
CTNNB1
(direct_complex)
Sierra et al., Genes Dev 2006
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
CTNNB1
—
BTRC
(coimmunoprecipitation)
Belaïdouni et al., Oncogene 2005*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, pull down)
Saha et al., Mol Cell 2008*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Chen et al., Mol Cancer Res 2012*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Wei et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Dehan et al., Mol Cell 2009*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Wang et al., Cancer Sci 2011*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Gao et al., Mol Cell 2011
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Li et al., Cell 2012
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Yang et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Cong et al., BMC molecular biology 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Kitagawa et al., EMBO J 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Peschiaroli et al., Oncogene 2010
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, pull down)
Kitagawa et al., EMBO J 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, two hybrid)
Hart et al., Curr Biol 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Hart et al., Curr Biol 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, pull down)
Hart et al., Curr Biol 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Su et al., Mol Cell 2008
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, unspecified method)
Winston et al., Genes Dev 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Latres et al., Oncogene 1999
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Liu et al., Biochem Biophys Res Commun 2004*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Dorrello et al., Science 2006
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Godin et al., EMBO J 2010*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(physical association, affinity chromatography technology)
Guardavaccaro et al., Nature 2008*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(association, x-ray crystallography)
Evrard-Todeschi et al., J Chem Inf Model 2008*
-
IRef Biogrid Interaction:
CTNNB1
—
BTRC
(direct interaction, enzymatic study)
Saha et al., Mol Cell 2008*
-
IRef Hprd Interaction:
Complex of BTRC-BTRC-SKP1-CTNNB1-SKP1-CTNNB1-BTRC-SKP1-CTNNB1
(in vivo)
Wu et al., Mol Cell 2003
-
IRef Hprd Interaction:
CTNNB1
—
BTRC
(in vivo)
Gao et al., Proc Natl Acad Sci U S A 2002, Ding et al., Trends Biochem Sci 2002*
-
IRef Hprd Interaction:
CTNNB1
—
BTRC
(in vitro)
Gao et al., Proc Natl Acad Sci U S A 2002, Ding et al., Trends Biochem Sci 2002*
-
IRef Innatedb Interaction:
BTRC
—
CTNNB1
(unknown, -)
Guardavaccaro et al., Nature 2008*
-
IRef Innatedb Interaction:
BTRC
—
CTNNB1
(unknown, -)
Latres et al., Oncogene 1999
-
IRef Innatedb Interaction:
BTRC
—
CTNNB1
(unknown, -)
Hart et al., Curr Biol 1999
-
IRef Innatedb Interaction:
BTRC
—
CTNNB1
(unknown, -)
Dorrello et al., Science 2006
-
IRef Intact Interaction:
Complex of RBX1-BTRC-CUL1-UBE2D2-CTNNB1-UBA1-SKP1
(ubiquitination reaction, enzymatic study)
Duda et al., Cell 2008
-
IRef Intact Interaction:
Complex of BTRC-CTNNB1-SKP1
(physical association, x-ray crystallography)
Wu et al., Mol Cell 2003
-
IRef Intact Interaction:
BTRC
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Kalra et al., FEBS Lett 2006*
-
IRef Intact Interaction:
BTRC
—
CTNNB1
(physical association, anti bait coimmunoprecipitation)
Godin et al., EMBO J 2010*
-
IRef Intact Interaction:
BTRC
—
CTNNB1
(physical association, anti tag coimmunoprecipitation)
Godin et al., EMBO J 2010*
-
IRef Ophid Interaction:
BTRC
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
BTRC
—
CTNNB1
(aggregation, confirmational text mining)
Gao et al., Proc Natl Acad Sci U S A 2002
Text-mined interactions from Literome
Novak et al., Cell Mol Life Sci 1999
(Alzheimer Disease...) :
In the absence of an activating signal, phosphorylation of
beta-catenin by glycogen synthase kinase 3 ( GSK3 ) acting in conjunction with adenomatous polyposis coli and axin/conductin
causes beta-catenin to interact with the
beta-transducin repeat containing protein which results in its ubiquitination and degradation
Angers et al., Nat Cell Biol 2006
:
Considered with evidence that the distinct Cullin-1 based
SCF(beta-TrCP)complex regulates
beta-catenin stability, our data on the stability of Dishevelled demonstrates that two distinct ubiquitin ligase complexes regulate the Wnt-beta-catenin pathway
Megy et al., FEBS Lett 2006
(Neoplasms) :
Phosphorylation of
beta-Catenin at sites Ser33 and Ser37 on the DSGXXS motif is
required for the interaction of beta-Catenin with the ubiquitin ligase
SCF(beta-TrCP)