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NOS2 — NPY4R
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Orlicek et al., Shock 1999
:
The src family-selective tyrosine kinase inhibitor
PP1 blocks LPS and IFN-gamma mediated TNF and
iNOS production in murine macrophages ... We report that the pyrazolopyrimidine
PP1 , a src family-selective tyrosine kinase inhibitor, potently
inhibits the production of TNF and
inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages stimulated with LPS, rlFN-gamma, or LPS + rIFN-gamma
Stovall et al., J Biol Chem 2004
:
PP1 , a selective inhibitor of src related tyrosine kinases,
blocked both the CpG DNA mediated tyrosine phosphorylation of vav1 and the CpG DNA mediated up-regulation of macrophage tumor necrosis factor secretion and inducible
nitric-oxide synthase protein accumulation
Lee et al., Biochem Pharmacol 2005
:
Moreover,
PP1 suppressed the expression of IFNbeta and
iNOS induced by TRIF, a MyD88 independent adaptor of TLR4
Kox et al., Vascul Pharmacol 2007
:
LPS also increased levels of
iNOS and this was also
inhibited by SU6656 and
PP1
Hirji et al., J Immunol 1998
:
Genistein ( broad spectrum protein tyrosine kinase inhibitor, 10 microg/ml ),
PP1 ( src family kinase inhibitor, 5 microg/ml ), polymyxin B ( protein kinase C ( PKC ) inhibitor, 100 microg/ml ), and Ro 31-8220 ( PKC inhibitor, 1 microM ) significantly
inhibited anti-CD8alpha- and anti-CD8beta stimulated NO production and
inducible NO synthase up-regulation, suggesting that tyrosine kinase ( s ) ( src family ) and PKC are involved in CD8 signaling