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ANPEP — IL10
Text-mined interactions from Literome
Huschak et al., Clin Exp Immunol 2003
(Craniocerebral Trauma...) :
Because lipopolysaccharide (LPS) and the anti-inflammatory cytokine interleukin (IL)-10 have been shown to be involved in the depressed HLA-DR expression on monocytes in trauma patients, we studied the in vitro
effects of LPS and
interleukin (IL)-10 on the expression of
CD13 on monocytes prepared from the peripheral blood of healthy volunteers
Kehlen et al., Cancer Res 2003
(Carcinoma...) :
In the undifferentiated thyroid carcinoma cell line 1736,
APN/CD13 mRNA expression could be
increased by epidermal growth factor, basic fibroblast growth factor,
interleukin-6 , and tumor necrosis factor alpha
Bank et al., Int Immunopharmacol 2006
(Body Weight...) :
Based on the findings that DPIV and
APN inhibitors
induce the TGF-beta1 and
IL-10 production and a suppression of T helper cell proliferation in parallel, and that particularly APN inhibitors amplify the suppressing activity of regulatory T cells, both peptidases represent a promising target complex for treatment of diseases associated with an imbalanced T cell response, such as inflammatory bowel diseases ( IBD )
Ponemone et al., Clinical and translational gastroenterology 2010
:
Leptin and
APN enhanced
interleukin (IL)-10 production by anti-CD3 stimulated LPL-T in IBD only