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MUC1 — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wei et al., Cancer Cell 2005
:
These findings indicate that
MUC1 regulates
p53-responsive genes and thereby cell fate in the genotoxic stress response
Wei et al., Cancer Res 2007
(Breast Neoplasms) :
The present studies show that
MUC1 represses activation of the
p53 gene and that MUC1-C occupies the PE21 element in the p53 proximal promoter ... The results also show that
MUC1-C increases the recruitment of histone deacetylases 1/3, deacetylation of core histones, and repression of
p53 transcription
Singh et al., J Biol Chem 2008
:
Phosphorylation of
MUC1CT by Met
enhanced its interaction with
p53 , which led to suppression of AP1 transcription factor activity through interactions at the MMP1 promoter, ultimately leading to reduced transcription of MMP1