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HIF1A — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HIF1A → TNF (increases)
  Evidence: Interestingly, although the molecular pathways are unclear, tumour necrosis factor (TNF)-a has been shown to promote HIF-1a accumulation, and this might involve a VHL-dependent step [33,34].

Text-mined interactions from Literome

Zhou et al., Mol Biol Cell 2003 : In tubular LLC-PK1 or human embryonic kidney cells, TNF-alpha induced accumulation of HIF-1alpha protein but not HIF-1alpha mRNA
Coimbra et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : The increase in HIF-1alpha expression induced by TNFalpha was partially blocked by pretreatment of the chondrocytes with inhibitors of NFkappaB or p38 MAP kinase
Zhou et al., Cancer Res 2004 (MAP Kinase Signaling System) : In tubular LLC-PK ( 1 ) cells, activation of nuclear factor kappaB (NFkappaB) by TNF-alpha resulted in HIF-1alpha protein synthesis as determined by [ ( 35 ) S ] methionine pulse experiments
Jeong et al., Life Sci 2005 : Our observations show that calcium, MAPK activation, HIF-1alpha , and NF-kappaB are necessary for ethanol induced TNF-alpha and TGF-beta1 expression
Yao et al., J Neurosci Res 2008 : Our studies showed that, unlike a murine microglial cell line ( BV-2 ), MO3.13 cells do not induce HIF-1alpha in the presence of TNFalpha
Görlach et al., Biochem J 2008 : In this issue of the Biochemical Journal, a study by van Uden et al. has supported these findings further, in which they have confirmed the binding of several proteins of the NF-kappaB family at the previously identified consensus site in the HIF-1alpha promoter and shown that TNF-alpha can also transcriptionally induce HIF-1alpha by this previously described pathway
Regueira et al., Liver Int 2009 : The aim of this study was to evaluate the effects of cobalt chloride ( CoCl ( 2 ), a hypoxia mimicking agent ), tumour necrosis factor-alpha (TNF-alpha) and toll-like receptor (TLR) -2, -3 and -4 agonists on HIF-1 alpha accumulation, and further on HIF-1 alpha mediated modulation of mitochondrial respiration in cultured human hepatocytes
Kuo et al., Biochem Biophys Res Commun 2009 (Breast Neoplasms) : TNFalpha induces HIF-1alpha expression through activation of IKKbeta ... Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK ) signaling pathways are involved in TNFalpha mediated HIF-1alpha accumulation and activation under normoxic conditions ... Here, we provide evidence showing that IkappaB kinase beta (IKKbeta) is required for HIF-1alpha regulation by TNFalpha ... We found that TNFalpha enhances HIF-1alpha protein expression in various breast cancer cell lines under either normoxic or hypoxia mimicking conditions, but has little effect on the HIF-1alpha mRNA level ... Treatment of cells with the IKKbeta inhibitor Bay 11-7082 reduced the TNFalpha induced HIF-1alpha expression, suggesting that IKKbeta is required in this signaling pathway ... Our findings indicate that TNFalpha induced HIF-1alpha accumulation is IKKbeta dependent, and may enable further understanding of the HIF-1alpha regulation by inflammatory signals